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The number of cells living inside a human body
is approximately 37 trillion.
Each cell has their own role, depending on their type.
For instance, red blood cells are tasked
with delivering oxygen.
White blood cells fight harmful things that enter the body.
Every single cell helps another
to keep working every day,
and that's how humans stay alive.
WELCOME TO THE LUNGS RIGHT LUNG - RIGHT WING
IMPROVEMENT WEEK EXCHANGE CHEERFUL GREETINGS
VEIN ANGLE SQUARE
This
is the red bone marrow,
where blood cells are born and spend their early days.
It is the blood cells' homeland.
Here, hematopoietic stem cells produce progenitor cells
which will later be sorted by category.
In this place,
the young precursors mature into cells called "erythroblasts."
It isn't a race, but do your best anyway.
Now of course
-let's try some practice deliveries. -And they are nurtured by macrophages.
Okay!
Hurry, we have to go fast!
-Here you are. -Thank you!
Huh?
Oh no…
Ms. Macrophage?
Hello…
How did you get all the way over here?
Ooh, my, my, my, my, my, my, my, my, my…
You know…
I always love to bully and destroy all you little red cells!
Target sighted!
Not even a fully formed cell!
Are you capable of taking me on?
You're safe now.
I'll be the greatest white blood cell!
Poke.
Leave him alone!
You know…
there's little I hate more than
cocky cells!
Yaa-ha-ha-ha! Ahh-hah--!
You two are safe.
Oh thank goodness.
I've been so worried.
Ms. Macrophage
There, there.
Don't cry.
Come, let's get back to the others.
Congratulations
on your denucleation.
Today, all of you become
mature red blood cells.
You'll receive oxygen in the lungs
and deliver it to places and cells around the body.
Well done on passing.
Remember not to get lost
and complete the missions you're assigned.
I will!
I'll become the greatest red blood cell.
Papa?
It's late.
Wake up!
Come on, seriously?
Papa!
You need to get up.
Papa, come on!
I said wake up!
Nasty.
C'mon!
Time for work! Let's go!
Wake up!
Good morning!
-What is that? -Hm?
Oh, tofu scrambles.
-Less calories, it's healthy for you. -I don't need healthy, though.
I just want eggs,
scrambled with--
Your blood pressure, blood sugar, uric acid, cholesterol…
They're too high.
You can't keep hiding these things.
It says you need to work on your diet, and get a re-examination.
I feel like I'm responsible.
-Ah! -Look here:
"Positive fecal occult blood test"?
What is that?
-That seems really bad. -Oh, that's not a big deal,
just a little
rear end issue.
This isn't funny, Dad.
You need to see a doctor.
Okay.
See you later!
I bring carbon dioxide to the lungs…
and then I get oxygen and deliver it around the body where it's needed.
I've got this.
I've definitely got this.
Okay.
Wh-what?
What?!
Uhh…
-Hey, hey, move it, move it, move it! -Oh, I'm sorry!
Watch where you're standing!
Oh,
there it is!
So this must be a vein entrance.
Okay.
Huh?
Hey, one-way traffic here!
Oh! I'm so sorry!
Huh?
One way?
Seriously?
Huh?
Quickly, go! Just go, get out of here!
Attack!
Find the redundant cells and kill them all.
This place and its residents are ours now.
Get away!
There's too many, what do we do?!
You're safe now.
Well there you are. Oh my, you look tasty.
I could eat you up!
Neutrophil Division White Blood Cell U-1146:
Invading germs exterminated.
Wait!
Thank you for saving me.
I was lucky you came when you did.
When I'm older,
and a little stronger,
I will
be a worthy red cell too.
I swear!
What do you want from me?
Oh, No, I…
Many thanks, sir.
For saving my life again.
-Just doing my job, that's all. -Okay! Bring 'em through!
-Coming through, coming through. -How many we got back there?
Thank you.
Uh, sorry, I mean…
You are very welcome.
Oh… Okay!
I'll kill them all.
I'll kill every last one of them.
It's a white cell.
-Whoa, watch out. -Those guys are ruthless!
I guess not.
Attention,
Helper T alarm raised.
We received word that pneumococcus is on the run inside the blood stream.
Stay alert:
Killer T cells are deploying.
The helper T cell and killer T cells?
The Helper T cells.
Macrophages like myself
will alert them to viruses or bacteria invading the body.
They form a battle plan and direct the killer T cells to attack.
And the killer T cells:
These are reliable cells that directly attack and defeat cells infected with
viruses or bacteria.
Hustle up!
Yes, sir!
Operational orders!
All targets are to be killed on sight.
Any wuss who lets a single invader go
gets the spleen, understood?
Yes, sir!
Those are the killer T cells I heard about, then.
This isn't good.
We need to kill them before they start dividing.
-Huh? -Take care.
Any cells carrying nutrients like oxygen are the infection's primary targets.
I was actually just on my way to the lungs to…
If we let this thing free
it'll attack each organ and eventually
seize the advantage and destroy the whole body.
The whole body…
Oh, wait a minute, hang on, don't leave me here!
The lungs:
Their role is to take oxygen into the body
and release carbon dioxide back into the air.
Here we are.
This is the lung.
Whoa,
look at this place!
Receptor has been triggered…
What is that thing?
It's a radar to detect intruders.
Where is it?
I know they're here… kill them all!
I guess a better design was out of the question.
It's definitely near here.
-I'll sweep the area for stragglers. -Oh--
okay!
I'm getting oxygen so I'll see you.
That leads to the bronchi.
Ah…
How embarrassing.
Kind of a klutzy one…
Finally here!
The alveoli:
Where oxygen and carbon dioxide are exchanged
between the air and capillaries.
Let's see…
this is where gases are exchanged.
Huh?
WHEN EXCHANGING CARBON DIOXIDE AND OXYGEN
DON'T RUSH - TAKE YOUR TIME DO IT WITH CARE
I should thank you!
Couldn't make the journey without your help.
This is
such a nice place to ambush unsuspecting little red cells.
Might as well have a little snack!
I'm gonna eat ya!
Huh?
Mr. White Cell?
The moment you walked away, the receptor went silent.
I wasn't completely sure, though.
Didn't think you hiding in the CO2.
How'd you get in here?
Should've studied more.
All white cells
can "migrate," so we can travel through the walls of blood vessels to reach
our enemies.
I came all this way, you're not gonna kill me now!
We're running.
Wha?
Where you going??
Come here!
Scamper all you like, but I got you cornered.
-You wimpy little cells! -Hey, red cell,
step back a little more.
Okay…
You're looking scared there, white cell.
Giving up already?
Hope you're both ready to meet your end.
Now die!
Huh?
The end has come for you instead.
Whoa…
Whoa, whoa, what the--? What're you doing?
-Bacterium successfully captured. -Let me out! What he hell is this?!
How do…?
-Let me out, come on! -Now commencing germ removal process.
No! No, not that!
-This is no joke! -So…
Let me outta here! Can you hear me?! Hey, let me out!
Little break sound good?
Hey! What are you doing to me? ! Let me out!
Wouldn't fight it.
That capsule is unbreakable from inside.
That's a bronchus you're riding in.
-Do you know what that means for you? -I don't know! I want out!
Where are you going?!
Lemme out, c'mon! Wait a second!
Hey! Don't you--
Whoa-whoa-whoa, wait…
-Easy now, easy! -Want something to drink?
-No-no-no-no-- -Um, sure…
No-no, what is this?!
You! Hey!
Let me down, let me down! Oh no.
Where is it gonna get taken now?
-Well, like I said: -Agh!
Watch out!
-Put me down! -This area's the bronchi.
Where are you taking me?!
Let me down!
Whoa-whoa-whoa, this doesn't look-
What is this? Hey!
SNEEZE 1
Sneeze Number One?
Commencing with countdown.
Three… two… one… zero.
No, no… hey, hey, hey, whoa, hey, whoa, stop!
Bye-bye, bacterium.
CELLS AT WORK!
Arata, good morning.
-How are you doing? -Oh, hey Niko.
Good morning…
You have a test, right?
Um, yes.
-Rooting for you. -Thanks.
See ya.
Let's go, let's go!
Adrenaline surge
let's go!
It's going haywire!
-Dopamine! -Huh?
-Endorphines! -What the…
Let them all flow!
Turn! It! Up!
Alright! Alright! Get hype! C'mon!
We lost control!
Adrenaline! Let's dance, get hype!
Let's goooo!
Jump! Jump! Jump!
Losing control!
Hey!
Oh! Are you okay, Niko?
Ah-
-I'm okay… -Are you hurt?
That looks ouchie…
What?
Mr. White Blood Cell!
You. We meet again.
What's going on here?!
What it looks like.
The outer walls of the blood vessels are being impacted and destroyed from outside,
causing the blood to flow out.
This is bad…
It's an ouchie!
An ouchie?
If you fall into that wound, there's no coming back to this world.
What? So it's really not good!
And that's not all.
We could get invaded
unless we get to the wound to close it up.
So what are we gonna do?
Nothing to worry about.
In situations like these we call the professionals.
They should get here in no time.
-They're up there. -Who are those kids?
-Slowly. Slowly. -Slowly. Slowly.
-Look out for the stairs! Be careful! -Slowly. Slowly.
Platelets, good to see you.
Greetings, teammates!
The platelet:
They are specialized blood cell components.
When blood vessels are damaged, they gather to close wounds,
and stop bleeding.
-Are we all ready? -Yeah!
-Everybody's fibrin is ready to go? -Ready to go!
Okay!
Let's go!
-'Kay! -Let us through please!
Oh, sorry…
Okay!
Now we'll connect our fibrin with the quackulation factors.
'Kay!
Hold on, everyone!
'Kay!
Are you ready?
One, two…
Heave ho!
Blood clotting:
Proteins in the blood called coagulation factors are activated,
and a mesh-like membrane called fibrin covers the injury as it solidifies.
Blood clot's done!
Yay! Hooray!
They're so great,
aren't they?
Oh?
Mr. White Cell?
-Okay, everybody can go ahead now! -Okay, everybody can go ahead now!
Mr. White Blood Cell!
Mr. White Cell?
Are you okay?!
'Kay, you too, miss!
Huh?
Oh, I'm sorry!
Huh?
What?
Are we stuck here?
When there's a hole in a blood vessel,
we all need to help seal the injury until it's repaired.
The platelets form the primary hemostatic plug.
Now this
-is the secondary one. -Really?
How much longer will we be stuck here?
Hard to say.
We stay until it dries up and the scab is formed.
Hey Boss!
Thank you again for dinner last night.
Look at you.
Niko-chan's making lunch for you, then.
She says I need to eat healthier,
she makes me eat less, too.
Aw man, you got a good daughter. At home, mine won't even talk to me.
Really?
Oh!
-That's good to go! -Huh?
-You're having that too? -This little lunch box is
just not cutting it, Boss.
You're really wasting her effort in trying to help you get healthier.
Hey boss, Wanna hit the bar tonight?
We were just there last night.
He's a lush, huh?
You been drinking every day?
A carbon monoxide warning has been issued.
A toxic substance has entered into the bloodstream.
All cells should take extra precautions when going out.
Wha?!
-Run! -Here, here, here, here!
Exhaustion build-up.
Over-eating and drinking.
Sleep deprivation.
This body, right now,
is under extreme stress!
Starved of oxygen!
But never give up!
Keep carrying that oxygen!
You cells!
Keep on going!
Yes, sir!
Aortic valve is open!
SEVEN BACTERIA GIVE ME OXYGEN IF YOU PITY ME
Hey wait!
You there, red cell.
-We're not getting enough oxygen! -Ah' I'm sorry!
I think we got orders from up top to prioritize delivery to main organs.
Marginal cells are supposed to just die?!
I'm very sorry, ma'am!
-We just get our orders and-- -Let's go!
Wait a minute!
I wasn't done talking to you!
-Hey! -Don't apologize for everything.
And you better get used to their whining, newbie.
Right…
Hey, you! Red blood cells!
You two quit slacking and get on it!
Sorry, sir, we're going as fast as we can!
Moron! What the hell!?
Now you got me apologizing like an idiot, new cell.
Um, right… sorry 'bout that.
Whoa!
Watch your step.
-Who's dumping all this trash back here? -Come on. Hurry up!
Quick! Let's go.
LDL?
Illegal dumping of cholesterol!
If we get more of these,
we might have heart disease in our future.
This way!
FROZEN SHOULDER - OLD PERSON SMELL
Agh! What is this?!
Alright, relax!
This is alcohol.
Alcohol?
-Not bad tonight. -Oh, man!
-That hits the spot! -It's pretty good, pretty good.
Ah, liver steak and um, guts!
Man, this sucks…
We gotta move outta here.
We'll be transporting alcohol all over the body if we--
It's true…
It tastes like alcohol…
Uh oh.
-I'm kinda… feeling a little dizzy… -Watch out, hey.
I'l show you how to release it.
The liver:
The body's chemical factory - an organ with a variety of functions - such
as substance synthesis, excretion and detoxification.
That was brutal, huh?
Here man, have a drink.
Okay…
Uh…
-What's this? -Alcohol is broken down with--
The ADH enzyme.
The ADH enzyme…?
Sometimes…
when there's an alcohol build-up that you need to release,
The hepatocytes will help you with that.
What's wrong?
You're not here to sulk, come on, have some fun.
If you really want…
I could help you drink it?
This body isn't…
in top condition, is it?
We can hardly even walk through the blood vessels…
They make us hit the oxygen supply quotas,
and the higher-ups don't care about us at all.
We have to stand up against this exploitative work environment.
He expired.
What?
We all end up like that;
food for the Kupffer cells.
Consumed and then recycled.
This is our cycle of life.
We only exist to keep delivering oxygen until we die.
That can't be!
But you'll be okay!
I'll be there to help you out!
If anything happens, then I'll-
After all our hard work…
we just…end up like that?
I'm not gonna take it!
Hey!
Newbie!
You can't blame the kid.
Unless this body changes,
our environment will never change.
It'll stay abusive forever…
I wonder who really is the one at fault.
♪Until two hours ago ♪It was just Tomoko alone
Ridiculous… Mm… Mm…
Thank you again for today.
If you feel like it, how about we go somewhere together sometime?
-What the… -What is he doing?
No, no, no.
He's gonna think this is creepy, though.
Maybe, maybe…
Ah--!
I-- Oh shoot…
READ
I'm so done.
-Okay. -What?
It's okay?
Uh…
Thank you so much!
When?
Uh… er…
so…
How 'bout Sunday next week?
Sounds good.
Yes!
Senpai is going on a date with me.
Why's it…
so cold?
Hmm?
-Feels hot…? -Ugh, so hot…
Huh?
This isn't right…
Man, I went the wrong way again…
When I'm older,
I will be a worthy red cell too.
I swear!
Okay.
Hi, excuse me. I'm trying to get to the kidney?
Ah!
Too close!
Your arc is too wide.
That's good!
What do you think?
The front-line white blood cell is strong, huh?
Work hard and you'll be as good as him.
You jerk!
You got some guts there, kid.
Mister!
Someday I'll grow into a white blood cell as strong as you are, sir!
-I'll be waiting. -Thank you… mister.
You know, that kid's a little bit like you were.
This is Macrophage.
Influenza B viruses are currently invading the body.
Roger.
Killer T cells are being dispatched.
Viruses like influenza B multiply much faster than bacteria, so stay alert!
Yes, sir!
Killer T,
good to see you here.
Nothing at all to worry about now that we're here to save the day! Let's go!
Yes, sir!
What the…
You're late.
NK, you punk…
You always gotta go over our heads and take credit, don't you?!
Keep it civil--
Ah-
Don't act so tough, Killer T.
You need Helper T's commands to take any action, don't you?
Lymphoblasts are stronger.
What the hell did you say?!
Too weak to enter the fight alone.
I, on the other hand,
I can move around freely inside the body all by myself.
Unlike you,
I'm born to kill diseased cells.
A Natural Killer.
The strongest white blood cell.
Yeah, natural, my ass, NK.
Natural narcissist would be a more accurate description.
Repeat that for me?
This is no time to fight.
More of them.
Coming this way.
Move.
I can handle these on my own.
Well now, we can't let her take all the credit,
can we, boys?
Let's go!
Yes, sir!
Stay here, Red.
This'll be dangerous
Okay…
-Ready! -Yes, sir!
You're just in the way, get going!
I- I'm sorry.
I had no idea there was a place like this in the body.
Here in the nasal cavity, one liter of mucus springs every day.
Then it becomes snot
gets rid of mold
infections, dust and dirt.
It's really nice…
What's wrong?
Huh?
You've just been staring at the ground.
I guess…
I've been jealous.
You do all these different things,
working hard to protect this body with the other white blood cells.
And you're awesome.
But all I do
is take oxygen from one organ to another.
But I mess up with that too.
Red blood cells have one task and I still can't do it.
That isn't true.
We white cells do patrol the body and find enemies,
but macrophages gather information on the enemy.
That allows helper T cells to give orders,
then killer T cells join us and we all defeat the enemy together.
We all take pride in the jobs that we do here.
And so should you, Red.
You allow us to fight.
The body needs you red blood cells to deliver your oxygen.
We're all teammates here
working together to sustain this body.
So…
don't worry, you're doing a good job.
Huh?
Thank you very much.
Well…
You're welcome, of course…
Senpai!
Good morning!
-Hey Niko! -I'm sorry to keep you waiting.
Mm-mm. Shall we go?
Sure!
Are you feeling okay now?
I heard you had the flu.
Ah,
I'm feeling a lot better.
Fully restored.
That's good.
Yeah!
We've got a first date!
Love is in the air!
Everybody get hype!
Let's go!
-Delicious. -Of course.
It's just so good.
-Oh, oh, really? -This corn's tasty.
Niko's dating, is she?
-She's growing up, huh? -Well, hopefully he's not weird.
-I gotta head out. -You weren't scheduled,
-so thanks for coming in. -Oh boy!
-Thanks! -Yeah, take care.
Yeeeah-
hooo! pew pew-pew-pew-pew! Yeah!
Love is in the air! Turn up!
Yeah!
-Whoa! -All right, make some noise!
Go! Go! Go! Go!
Everybody jump! Hey! Hey!
Come on!
Wooo!
Lovey-dovey love dance!
Super-soaked love dance!
Everybody, get hype and dance!
It's beautiful.
So sparkly.
I haven't been here in so long.
Oh yeah?
Yeah.
When I was a kid,
during school vacations,
mom would take us here a lot.
So I always liked the aquarium.
You're a little too old for that now, huh?
Well, I would if I still could.
She died, though…
when I was nine years old,
illness.
I had no idea…
So…
is that why you're aiming for med school?
Yeah.
Oh…
Actually, this scarf…
Mom was in the hospital when she started this.
She had to stop halfway through…
Here. Look.
The stitches are looser and uneven starting here.
You see, dad…
wanted this gift from my mom to be completed no matter what,
so he knitted the rest of it.
I like it a lot.
You're so grown up compared to me.
Not really, no.
I will never lose I will never bend
If my will was stronger Than anyone else's then I-
Ah!
Uh-oh…
Listen men, don't fear death!
We're the strongest muscle because we act as one.
Until we hear from up top, you keep it tight!
Not one leak!
Don't give ground to those internal sphincters!
-You give this battle your all! -Let us out!
Take pride in today!
-We can't take it! -You don't move for anyone!
-The strain, it's just too much! -Not a poo gets through!
No!
-Oh no, I'm slipping… -Hey!
You all will stand and hold with all your strength!
-Yes sir! -Excuse me, guys…
Hold firm, men!
-Um. -I know you boys can pull this through!
I brought oxygen for you.
Yes sir!
So where…!
-Set it down in here. -This is the final stand!
-Don't give in to the pressure! -You're in a danger zone!
What?
Rookie…
-I can't stand by and watch you die. -So let's go!
Let's GO!
-Last time was a real "this place" show. -Yeah!
I remember the timing could not have been worse…
-we lost good men that day. -Hold the line, muscles of the hole
Senpai?
-Are you okay? -Act as one, and don't lose control!
Yeah. We're headed to the gonads next.
-We should hurry. -Hold it till the cortex says to go!
Seriously?
What did I do to deserve this again?
Newbie… Bad news…
Rectal pressure is increasing!
Now entering dump mode!
-Dump mode…? -Alright, clear the way!
It's beginning…
it's gonna evacuate!
-What is that? -Let us out!
Let us out!
TO MAKINOUCHI REST AREA CROWDED
Hold it…
We're in the blast zone, rookie!
We gotta run!
Red alert!
Block defecation immediately! Repeat, block defecation immediately!
Close the anus!
Shit! Let's go! Rookie!
What are they all doing?!
The brain sent an order down, no evacuation yet!
Senpai!
Come on, please--
-♪I will never lose ♪I will never bend -That's right… I won't lose or bend! Huh?
Oh no, are you kidding?!
Don't let out even a single drop!
Oh god, please…
Oh, please…
SAY NO TO HOLDING! VIOLATION OF POO'S RIGHTS!
LET US OUT! WE CAN'T WAIT!
That stench…
It's so bad… what's the body been eating
to make it smell like that?!
Push harder, come on!
They're starting!
, Thank--
I… thank you…
What are they doing?!
-The brain said we can't let them out! -It's the internal sphincters! Get back!
Hurry, let them through!
-Why are you keeping them back?! -Neural signals don't get to those guys.
They're simple muscles with just one job:
push feces out when it gets to the rectum.
They're idiots!
This is bad…
If this keeps going, they'll break through!
Hold this position, rookie
or we'll be flushed right out with the waste!
GO!
Push them back now!
Help us!
Wh- where are they going?
Wait.
-Was there a leak? -No, but it's bad:
anal fissure.
And it's bleeding?!
It hurts…
Just how much is this body going to make us suffer?!
Go ahead.
Oof…
Almost…
Oh no…
Thank you…
Hang on!
I…
-can't take it… -Stay strong!
Newbie!
Ah!
Please-!
Gate opening!
-Gate opening! -Open the anus!
Newbie!
Senpai!
Are you okay there? Newbie?
Yeah…
I swore to you.
That, "if anything at all happens to you,
I'll be there to save you."
Senpai…
Let's get out of this awful place.
We need to hurry to the next stop on the route.
All right, next stop…
gonads.
Round two…
There's a second surge!
Open it up again!
-Senpai… -Don't let me go…
Hold on!
-Don't you ever let me go! -I won't!
Let them flow, let them flow!
-Let them flow! -Listen, Rookie!
I'm gonna see you…
at the gonads!
Senpai!
Newbie!
I won…
I guess it's kinda cringey.
Ah,
uh, thank you…
for everything today…
Thanks to you too.
Senpai?
Hm?
Uh, d-…
I really…
I…
I really
had a lot of fun today.
I really
I really appreciate it! Uh,
so, I'll
see you
at school.
Niko!
Will you…
Will you go out with me?
Huh?
Yes! I'd…
I'd really love that!
You're serious?
Heck yeah!
Thank you!
This is so great!
Thank you.
Um…
-I… -I--
It-- it's
my pleasure.
It's my pleasure as well.
Oh. Excuse me for a moment.
Oh, sure.
Hello?
Where?
Papa!
Whoa! What is it?
Your boss told me you collapsed in the bathroom.
Pretty crazy, Niko.
I was in the toilet,
got real dizzy,
and then apparently fainted.
I got scolded by a doctor who said
I neglect my health.
What? Neglect…?
-You still hadn't gone? -Guess not.
Come on dad, listen to you!
Why can't you put a little care into your own health?
Okay…
I will.
'Scuse me.
You Niko's boyfriend?
Ah- here.
Sorry, honey.
I'll go to sleep soon, okay?
Are you okay?
Oh.
Here.
This turned up in your father's truck.
I heard
he's always telling his coworkers
how you make him a proud father.
He said that, "Unlike her good for nothing dad,
she's smart, she's going to med school."
"I'll need more money for her tuition, so please give me more work."
I heard that's what he asked his boss.
That's why he went in today on his day off.
Let's chat.
It's been 14 days since you were born as blood cells.
While your peers have matured into myelocites,
you two seem to have stopped as myeloblasts
and haven't grown at all.
Huh?
At this rate, the ability to differentiate will be lost.
The body won't see you as abnormal,
and cells like you could multiply,
which will then jeopardize our ability to create healthy blood.
Are you saying we're abnormal?
Regretfully,
you aren't needed in this body any longer.
I'm sorry.
-No way! -Get rid of these two.
Sir!
-No, no! No, no, stop! Please! -You're coming, too.
Let go!
I'm gonna be a worthy white cell like I said, let go!
Don't let him go!
No more of that.
Okay?
-Now let's go. -I don't wanna go!
Just let me stay!
What did…
What did I do to you?!
The hell is that?
ONE MONTH LATER
Wellp, I'm done!
Oh, I'm running late.
-Hey. -Hm?
I think from now on
I won't eat so much.
What?
I got a blood test,
at the doctors yesterday,
all results improved
It's all about the diet!
Okay, okay, I got it.
Then I'll stick with the smaller portions.
Yeah. Here,
I made your lunch for you.
You get the dishes.
Sure thing.
-Hm? -Hm?
Your leg…
what'd you do?
Oh,
I don't know.
-Looks like I bumped it somewhere. -Oh.
See you later.
Sure.
-Oxygen delivery, thanks for waiting. -Mhm.
I just need your hanko here.
You're prompt as always. Thank you.
No problem,
it's what we do.
-I'm sure I'll see you again soon. -I'll be counting on you.
Okay!
I did it!
Took the blood stream all the way around and didn't get lost.
Next up, I'm headed for the small intestine…
She's become reliable all right.
Okay!
Ow!
Are you okay?
Mr White Blood Cell! I'm sorry!
No, it's okay…
I should pay better attention.
-Platelets? -Oh! Greetings, teammates.
Have you seen any more of our friends lately?
Not very many, no.
Have you?
No, me neither…
What's going on?
Not many of us have been around,
so we're having trouble healing bruises.
That is odd…
I wonder where they went?
Maybe they're lost somewhere?
You alone?
Yeah.
Though it's strange…
Lately it's been quiet.
Not too many white cells around.
-That's what I said. -…I swear…
-ugh, whatever -You should just tell
her that you're busy.
Niko.
Oh, Arata. Good morning.
What happened?
Niko, what's wrong?
Niko?
Are you okay?
Please make sure to check in fifteen minutes prior to appointments.
What?
I will be reviewing the detailed exam results,
after which I can explain
any routes for treatment.
Right now, she has a low platelet count and her
whole body is prone to bleeding.
Therefore,
she needs immediate blood transfusion in order to start receiving treatment.
Sir?
Mr. Urushizaki, are you okay?
Y-Yeah…
So, Niko…
thanks to her…
I'm eating healthy!
I feel like I can take on the world.
She needs to get well.
Doctor.
Whatever I can do…
to help her live.
Just…
Niko is… she's all I've got, doctor.
Please save her.
-I'm begging you! -Okay.
Leukemia…?
Yeah.
Acute…
myeloid leukemia, I think it's called.
So, in your blood,
you have red cells, white cells, and platelets, you know?
So right now… the nasty-looking cells…
are increasing…
So…
What do we do next?
Yeah… so that…
If we just let them be,
you won't have as many normal blood cells
and that's not good.
Uh, so, the next step is…
Chemotherapy.
That's what they do.
Anti-cancer drugs.
Mm…
but, I mean…
Well, you know…
You'll be okay.
Yeah?
I swear you'll be okay.
Mhm…
Why don't…
Why don't you take me instead…
Why Niko?
Why is…
Why is this happening?
Ahh, why is this so hard?
Well, you are pretty clumsy, aren't you?
Come on.
I guess you
had better heal up quickly so you can finish it.
I'm back.
Hello.
Mama, guess what?
I got asked to join the field day planning club.
Oh?
I'm so thrilled for you, that's great!
-It's exciting -Yes, it surely is.
Ma'am? Are you still with us?
Yuko.
Stay strong, Yuko.
Mama! Mama!
Let's start 'pressors.
Right away.
Yuko.
Mama!
Taking donors all day, blood donors!
Anybody have time? It's just a few minutes.
Blood types A and O are especially needed.
We can assist you right away.
We'll be taking donors just a few more hours.
Hey look!
Finally got around to fixing up these roads.
Yeah.
It's starting to look pretty good around here.
What the hell is that?
Here's oxygen. Please feel better.
Give me some too.
Yeah, I'm on my way!
-I need some too. -Here you go.
-I need oxygen. -Okay
Here you go.
-Over here too. -Ah! I'm sorry! I'm sorry!
Need oxygen… hurry…
Here.
Leukemia cells are rapidly multiplying in the body.
Please take care.
Reinforcement squad's here.
Thank you for coming.
Are you okay, Red Blood Cell?
I'm fine, yes.
We'll deliver the oxygen, we're determined to.
We're counting on you.
Everybody ready to go?
Do you have oxygen?
Uh, yeah.
Uh,
-could you… tell us what's going on? -There'll be time for that later.
Oxygen's here.
Be careful out there.
There's no telling where cancer cells could be hiding, so stay alert!
Yes, sir.
Moron.
When you're always so loud, your adversaries can hear you.
You're so damn cocky, you know that?
Keep it down.
I'm not like a cowardly T-cell, always hiding behind my allies.
Hey, you wanna say that again?!
Be quiet.
We have a guest.
HANDLE WITH CARE DEFECTIVE PRODUCT
It's been a while.
Big brother.
"Someday I'll grow into a white blood cell as strong as you are, sir!"
The boy…
you were the little one.
I'll be waiting.
Thank you, mister…
So…
you've been waiting for me
all along?
Mister! Let me fight you one-on-one again.
See if I'm any stronger.
How 'bout I fight you?
A rejected cell!
Let's do it!
Huh?
Who's this brute?
I'm talking with my older brother right now.
Attention cell workers, leukemia has been detected
throughout the body.
The cells are rapidly spreading to the lungs and spleen.
They've invaded the lymph nodes and they're headed to other organs.
Killer T's are being summoned.
That's a waste.
We're growing exponentially now.
-So there's more and more and more of us. -Enough.
We maintain this body and it needs us.
It doesn't need rejected cells.
What the…
You don't really believe that, do you?
Weren't you waiting for our rematch?
Fight me.
Let's see if I can beat you.
I'm sorry.
I can't let you pass.
Even my white cell big brother treats me like a defect.
Then, I'll kill you.
Reports say that the red bone marrow is being overrun with leukemia cells.
Head there immediately.
This isn't good.
Cell start their lives there.
Blood cells will stop being created.
We cannot let them occupy the red bone marrow.
We should hurry.
We have to get oxygen to both intestines next.
Hang on a minute.
Can we break for a second?
We don't have time for breaks.
We have to get oxygen to the weakened cells.
Okay.
What the-?
What the hell's going on?
It's those things.
They're sent to destroy leukemia cells.
They can't discern targets, though.
Healthy and helpful cells will be taken out as well.
Anti-cancer agent?
ANTI-CANCER AGENT
Move now.
NK.
I'm fine.
Hey! There's even more!
They're still going strong…
The missiles…
They aren't doing anything, they're not affected.
Shit, look out…
where the hell are they all coming from?
ANTI-CANCER AGENT
Are you okay?
Arata, can you get her some…?
Yeah.
I'm sorry.
I'm sorry, dad.
What do you mean?
There's nothing to be sorry for.
-I'm sorry. -No…
Can you… drink water?
Okay.
Ah, thanks. Okay.
NK.
Are you okay?
More over there…
It just never ends.
We're low on oxygen.
Why are the red blood cells slacking off?
We'll all be killed if they can't make another run.
The red cells are on their way.
Hold out a little bit longer,
they'll get us that oxygen.
Hey.
You guys really still think we can win?
Didn't know you'd give up so easily.
We make our stand and we beat them back!
Or this body will perish.
You get to the red bone marrow and I'll hold these guys off here.
NK, don't push too hard!
I don't take orders from you!
I fight by my own will.
You really are such a narcissistic cell.
I'm not letting you take all the glory from us today.
I'm ready to give these invaders hell!
Captain!
Hey White Cell!
This corridor's locked down.
Red bone marrow is our only hope now!
Let's go!
Yes, sir.
White Blood Cell, hurry up and run!
Stop dancing around!
Hurry and go!
What is it?
This… is never going to work.
You don't really think our pitiful efforts
can do anything at all to change this situation!?
Take a good look.
We are the only red blood cells left.
No matter how hard we try, our oxygen supply won't be enough.
It's clear our body's coming to an end.
I'm just scared.
I just want to feel safe again.
You think I don't?
You think we all aren't scared?
We're terrified.
But even so…
we all want to protect this body at all costs.
I won't run away.
So no matter what,
our duty is to keep delivering oxygen to cells.
It's what we're trained to do.
She's never whined or complained once since she was little.
Even when Yuko passed…
she was the one comforting me.
Here, look.
DADDY, CHEER UP. FROM NIKO
I'm a pathetic father.
Truly lousy.
I can't do much, you know?
So let's…
you and I…
support her how we can.
Yeah?
I beg you.
Sure,
of course I will.
Mr. Urushizaki,
-Niko is… -What?
Are you okay?
BP is dropping.
Hold the chemo.
-Run saline wide open. -Niko,
On it.
Niko.
-Five liters of O2 by mask. -Yes, sir.
Yes, sir.
-Get a 'pressor ready as well. -Okay.
Niko? Can you hear me?
NK.
-Niko, -Niko,
-Honey, hang in there Niko! -can you hear me?
Securing the mask.
-Starting O2, five liters. -Niko.
Niko.
Can you hear me?
Hang in there!
Niko!
Are you okay?
Hey!
Killer T.
I had fun today.
Sometimes it's good
to fight as a pack, isn't it? It's not bad.
Hey.
Hey!
Damn it.
Come on, you idiot!
NK, you know what?
I truly envied you, NK.
I was jealous because you could fight without taking
stupid orders from anyone!
Screw you!
Go.
Here
We're countin' on ya,
White Blood Cell.
Leukemia cells are also appearing in the pancreas area.
As well as in the small and large intestines.
Killer T, get over there immediately!
Killer T?
Respond.
Or…
They're here already.
We're able to fight…
thanks to you red blood cells constantly delivering oxygen.
I'm counting on you.
I need to…
keep going…
For now, her body is holding up, miraculously.
That said…
I'm not sure how much longer Niko will survive in her current state.
Eh, so, what now?
A bone marrow transplant…
is now her only option.
As soon as we find a donor, we'll begin radiation therapy.
You said… radiation?
To prevent the immune system from attacking the new bone marrow,
a pre-transplant procedure will use radiation
to destroy all the cells in her blood.
Hey, here!
I've got some oxygen right here.
What are you doing?
Deliver that oxygen, hurry, let's go!
Behind you!
Ms. Macrophage?
Hello Red Blood Cell.
Why are you here?
Didn't I tell you?
I have many roles.
I'm more than just the new cells' teacher.
I'm also a killer.
You need to hurry and go now.
You have a mission to fulfill don't you?
I do.
Let's go.
No.
I'm gonna stay here
Ms. Macrophage will need oxygen for her mission.
No matter what happens,
the oxygen will be delivered.
It's the job we're here to do, isn't it?
Oxygen here!
Mr. White Blood Cell?
You're still alive!
Red… Cell…?
I have oxygen for you.
I'm sorry it took so long to find you.
Thank you,
Red Blood Cell.
Of course.
We'll start the radiation therapy now.
Help me.
Someone.
Help me.
What was that light?
What do you think is going on here?
Why is everyone getting vaporized?
I have no idea.
If we lose any more allies, we're in a bind
the body won't be able to sustain itself.
We need to go.
In our hometown,
the red bone marrow,
the hematopoietic stem cells that once produced us should still be working.
You need to gather some oxygen,
and bring it to the stem cells.
That way,
they can start to make some more allies for us.
I'm not…
I'm not sure if I can get there alone.
You'll be fine.
The whole way I'll make sure you're protected.
We gotta go.
We have to run.
We're almost there.
Okay.
Hey,
I'm a little hungry.
Why don't you give me that oxygen?
I'm not doing that.
I can't give it to you.
I see.
I'll kill you then.
Mr. White Cell.
Red Cell.
You keep on going.
No,
-but you're… -Hurry and go.
You complete the mission, you hear?
Okay.
Mister.
Sorry…
You left me with no choice but to kill you.
Hm.
So I…
am a mutant defect to the white cells like you.
Just do it.
You might as well kill me.
Why is it…
I'm treated like I'm worse than nothing?
Why!?
Why do I have to die?
It's not fair!
What reason did I give you to hate me?
I was dragged into this world.
I wanted to be a heroic white cell like you.
How's it feel, Mister?
Being extinguished by a so-called defect like me.
Frustrated?
You must be.
Now say this:
Say you're weaker than I am.
You're already done?
Too bad then.
Thank you very much.
I'll leave her with you.
Niko, are you okay?
There are hardly any cells in the bone marrow
now, so we need to be very cautious.
Doctor,
is there anything
that I can do for her?
I think it's best to…
stay with your daughter for the procedure
until we know her body's healing.
THINGS DADDY USED TO LOVE
BUT WHAT I'VE ALWAYS LOVED THE MOST IS…
NIKO'S SMILE
I LOVE YOUR BIG SMILE MORE THAN ANYTHING IN THE WORLD
HE SAYS SO TOO.
I HEARD YOUR IMMUNE SYSTEM IMPROVES WHEN YOU SMILE
JUST A LITTLE MORE! HANG IN THERE, NIKO
One two
-Go! Go! Niko! -Go! Go! Niko!
-Go! Go! Niko! Go! Go! Niko!
Go! Go! Niko! Go! Go! Niko!
-Wow -Wow
Thank you.
No way.
You're delivering oxygen to help your friends multiply?
Too bad.
That's a waste.
What?
Nobody is coming to rescue you.
You and I should be allies, we were born in the same world.
Why do we have to fight each other like this?
We're not allies.
You guys tried to eliminate me first.
That's why I
will change this world for the better.
A world where we can live freely
from the fear of getting utterly destroyed.
I won't let you do that.
Never.
Oh you're funny.
You're just a lowly red blood cell.
Now die, weakling.
Mr. White Cell.
You didn't study enough.
All white cells can "migrate";
we travel through walls to meet our enemies.
Why is it?
I just wanted that sense of…
belonging with the other white cells.
I don't
have the ability to save you.
Nor can I heal you
or let you live at all.
You must be destroyed.
That is our duty.
I suppose…
you're strong.
You're strong after all.
Sorry.
Some day, I'll grow into a white blood cell
as strong as you are, sir!
The body
is in a state of devastation.
All cells,
please take the necessary steps to protect yourselves.
What will happen to us?
Are you feeling okay?
I still have some oxygen.
Here.
I don't need it.
There are more cells…
that need this oxygen to keep on living.
Yeah but…
To protect and maintain this body,
we need you red cells to keep working.
Whatever happens…
deliver that oxygen.
Swear to it.
It was you…
you're the one who…
Red Blood Cell.
You've become worthy.
We need you…
Red Cell…
I'll do you proud.
White Cell, please…
Don't leave us today.
Please don't.
Mr. White Cell?
Mr. White Cell!
Thank you for everything.
Please, please…
Oh,
here's oxygen. Please feel better.
Thank you.
I have oxygen…
Okay. We'll begin the bone marrow infusion.
Congratulations.
Looks like your newly injected stem cells are engrafted?
So now
healthy regular blood cells
are starting to get made again.
Right, Doctor?
That's exactly right.
Doctor,
-thank you for all your help. -No, no,
Niko, you've come this far
all on your own strength.
Without your own strength, your body couldn't have made
it to the transplant.
You should thank your cells,
they put in the real work.
Thank you.
Dear erythroblasts who are still small and cute,
I'm a red blood cell who used to work in this body.
I'm a little slow and always lose my way.
Unlike white blood cells that can fight off bacteria and viruses,
all I could do was deliver oxygen.
And I felt insecure.
But now, I see myself as an important
part of this body, helping to protect and sustain it.
It's not about who's superior or who's stronger.
None of us can survive alone,
so we support and complement each other.
That's how we all work together to maintain this body.
I loved working with these friends of mine.
The number of cells in a human body is approximately 37 trillion.
Most eventually die from external threats or due to the end of their lifespan.
They pass on their duties to newly produced cells.
We are cells at work.
And now I'm passing the work on to you.
Please keep delivering oxygen to sustain this body.
From your senior red blood cell.
We're about to get going, everyone. Oh!
What are you doing? Our next class is starting soon.
Okay!
ONE YEAR LATER, SPRING
Dad, come on!
We're running so late!
Sorry, sorry, I couldn't pick a tie!
It's not like it's your school entrance ceremony.
You're entering med school, though.
Can't let 'em look down on you.
-Gotta look sharp, don't I? -Okay, okay.
We really should hurry, we're gonna be late soon.
You don't have to come, you know.
No, no! I mean, Arata…
-you're like family now, right? -Well…
Ooh, sir…
-Sure that tie isn't a bit casual? -I agree.
-One sec -Why are you saying those
kinds of things? You're okay!
Hurry.
Huh?
Got a cold?
No,
I think this is…
Heave ho.
Heave--
Here, take care.
Thank you, miss!
You're very welcome.
Alert, alert.
Cedar pollen allergens have entered the drainage duct near the eye's
mucous membrane.
Allergens?
Where'd they go?
Where're they hiding?
Kill them all.
Kill them, annihilate them!
What is it, Red Blood Cell?
Oh, nothing.
I don't know why, but I feel like we know each other.
It's right near here.
Cedar.
-Cedar. -Cedar.
This is White Cell Neutrophil U-8996.
I've located the target allergen.
Going in to eliminate.
Mr. White Blood Cell?
So will I
be seeing you later?
We work together, don't we?
I'll see you around.
Yeah, I hope so.
Until then…
Put them down.
Slaughter them, annihilate them!
Ce- dar.
Well,
let's get to work.
Heave ho. Heave ho. Heave ho. Heave ho. Heave ho. Heave ho. Heave ho. Heave ho.
Heave ho.
RED BLOOD CELLS: THEIR JOB IS TO DELIVER OXYGEN TO CELLS
THROUGHOUT THE BODY AND CO2 TO THE LUNGS.
IT TRAVELS AROUND THE BODY IN LESS THAN A MINUTE!
90 DAYS LEFT UNTIL THE EXAM!
WHITE BLOOD CELLS PROTECT THE BODY FROM
BACTERIA, VIRUSES, AND OTHER FOREIGN SUBSTANCES
THAT HAVE INVADED THE BODY FROM THE OUTSIDE.
RECEPTORS: RADAR-LIKE THINGS THAT DETECT BACTERIA AND OTHER ORGANISMS.
TYPES: NEUTROPHILS, EOSINOPHILS AND MACROPHAGES.
KILLER T CELLS RECOGNIZE AND DESTROY FOREIGN CELLS SUCH AS
VIRUS-INFECTED CELLS AND CANCER CELLS - SCARY!
DEPLOYED ON THE ORDERS OF HELPER T CELLS - ARE THEY FRIENDS?
SCOPE OF THIS WEEK'S REVIEW: NATURAL KILLER CELL BORN WITH
THE ABILITY TO KILL EXTERNAL ENEMIES AND ATTACK THEM AT THEIR OWN DISCRETION.
I'M GOING TO GET INTO MEDICAL SCHOOL FOR SURE!
MACROPHAGE: A TYPE OF WHITE BLOOD CELL
THAT ASSISTS IN THE DIFFERENTIATION AND MATURATION OF ERYTHROBLASTS.
THEY ALSO FIGHT AGAINST FOREIGN SUBSTANCES LIKE BACTERIA
AND PASS THIS INFO ONTO HELPER T CELLS.
HELPER T CELLS: COMMANDERS THAT RECEIVE NEWS OF FOREIGN INVASION
AND DECIDE ON THE STRATEGY OF ATTACK.
SUMMARY: HELPER T CELLS ORDER TO MOBILIZE KILLER T CELLS
MACROPHAGES - ANTIGEN INFO
HEPATOCYTE: CELLS THAT MAKE UP THE BULK OF THE LIVER.
THE LIVER HANDLES THE METABOLISM AND DETOXIFICATION OF SUBSTANCES.
THE CHEMICAL FACTORY OF THE ORGANISM THE LIVER CONTAINS 2,000 ENZYMES
PNEUMOCOCCUS: PATHOGENIC BACTERIA CAUSING PNEUMONIA, ETC.
HIGHLY VIRULENT BACTERIA WITH CAPSULAR MEMBRANES
STREPTOCOCCUS PYOGENES: INDIGENOUS BACTERIA FOUND
IN THE PHARYNX, GASTROINTESTINAL TRACT AND SKIN.
RARELY REFERRED TO AS 'FLESH-EATING BACTERIA'
CAN CAUSE SEVERE INVASIVE STREPTOCOCCAL DISEASE
STAPHYLOCOCCUS AUREUS: BACTERIA INDIGENOUS TO THE SKIN AND PORES.
CALLED 'STAPHYLOCOCCI' BECAUSE THEY LOOK LIKE CLUSTERS OF GRAPES
INFLUENZA VIRUSES: VIRUSES THAT CAUSE INFLUENZA. HIGHLY CONTAGIOUS,
SAID TO MULTIPLY UP TO 1 MILLION IN 24 HOURS.
HAD A FEVER; IT WAS HARD. 30 DAYS TO GO UNTIL THE EXAM.
TAKE GOOD CARE OF YOURSELF!
LEUKAEMIA CELLS: LEUKAEMIA IS A SO-CALLED CANCER OF THE BLOOD.
LEUKAEMIA CELLS ARE CANCEROUS CELLS DUE TO A GENETIC MUTATION THAT OCCURS
DURING THE GROWTH PROCESS.
5,000 CANCER CELLS ARE PRODUCED EVERY DAY IN HEALTHY PEOPLE?
EACH TIME, IMMUNE CELLS KILL THEM
BONE MARROW FLUID
CELLS IN THE BONE MARROW THAT PRODUCE BLOOD CELLS SUCH AS
RED BLOOD CELLS, WHITE BLOOD CELLS, AND PLATELETS.
THE BRAIN IS MADE UP OF NEURONS
THERE ARE MANY NEURONS IN THE HUMAN BRAIN.
THERE ARE ABOUT 100 BILLION OF THEM!
EXTERNAL ANAL SPHINCTER IS A MUSCLE THAT CAN BE MOVED AT WILL.
THE INTERNAL ANAL SPHINCTER IS A MUSCLE THAT CANNOT BE MOVED AT WILL.
AN ANAL FISSURE POSITIVE FECAL OCCULT BLOOD TEST
PLATELET: A TYPE OF BLOOD COMPONENT THAT ASSEMBLES WHEN BLOOD VESSELS
ARE DAMAGED AND CLOSES THE WOUND. THEY ACCOUNT FOR LESS THAN 1%
OF THE TOTAL BLOOD. RARE CHARACTERS
THE SCOPE OF THE SHORT EXAM ENDS HERE.
CEDAR POLLEN IS THE MAIN CAUSATIVE AGENT OF HAY FEVER, WHICH IS VERY PREVALENT
IN EARLY SPRING.
HAY FEVER IS AN ALLERGIC REACTION CAUSED BY AN EXCESSIVE IMMUNE RESPONSE
TO POLLEN ENTERING THE BODY. SNEEZING, RUNNY NOSE, ITCHY EYES, ETC.
SNEEZING: A REFLEX REACTION THAT OCCURS WHEN THE BODY TRIES TO EXPEL
FOREIGN SUBSTANCES SUCH AS DUST OR VIRUSES.
ALSO CAUSED BY ALLERGIC REACTIONS OR IRRITATION OF THE NASAL PASSAGES.
'PHOTIC SNEEZE REFLEX' - SOME PEOPLE SNEEZE WHEN THEY SEE THE SUN!