1 00:00:02,000 --> 00:00:07,000 Downloaded from YTS.MX 2 00:00:08,000 --> 00:00:13,000 Official YIFY movies site: YTS.MX 3 00:00:09,661 --> 00:00:11,315 [whispers] 4 00:00:11,576 --> 00:00:13,230 [phone vibrating] 5 00:00:15,189 --> 00:00:17,147 That is yuck, right? 6 00:00:17,191 --> 00:00:18,931 [laughing] What's yuck'? 7 00:00:19,497 --> 00:00:22,326 -[Jack] Blood. -[Lisa] Yeah. It is what it is. 8 00:00:22,370 --> 00:00:24,067 [phone vibrating] 9 00:00:24,111 --> 00:00:25,460 Okay, push hard. 10 00:00:26,548 --> 00:00:28,289 -Oh! -You see it's here! 11 00:00:28,332 --> 00:00:31,031 I know and then I have to squeeze it. 12 00:00:32,597 --> 00:00:35,078 -Is it out? -Look at how much blood there is 13 00:00:38,168 --> 00:00:39,909 [sighs] 14 00:00:41,650 --> 00:00:45,784 Mmm, what does that say? Do it? 15 00:00:45,828 --> 00:00:50,354 -No? OK. Two, ni--, go ahead. -...Two, nine, four. 16 00:00:50,398 --> 00:00:52,052 Mmm, yeah. 17 00:00:54,054 --> 00:00:57,057 Sucks, [sighs]. Weird! 18 00:00:58,884 --> 00:01:01,104 I don't know, Jack 19 00:01:01,148 --> 00:01:02,932 Yeah, I know. This is just not good. 20 00:01:02,975 --> 00:01:04,455 I don't know why it's going up. 21 00:01:05,543 --> 00:01:07,371 I have to talk to my doctor. 22 00:01:09,069 --> 00:01:13,073 The average person has three traumatic events in their life. 23 00:01:14,726 --> 00:01:18,165 Waking up in the ICU was one of mine. 24 00:01:19,557 --> 00:01:22,038 Maybe we can test daddy's blood sugar 25 00:01:22,256 --> 00:01:24,345 -Let's see what daddy's is. -[Guy] Mhmm. 26 00:01:25,955 --> 00:01:28,784 [glucometer beeping] 27 00:01:30,002 --> 00:01:32,048 -There it is. -There. 28 00:01:33,049 --> 00:01:35,878 -Hey, look! -Yeah. Okay. 29 00:01:38,707 --> 00:01:41,362 -Nine, six. -Wow! 30 00:01:43,538 --> 00:01:48,064 I've spent the last 30 years trying to outrun my disease, 31 00:01:48,543 --> 00:01:50,284 but it's not working. 32 00:01:52,373 --> 00:01:56,594 The irony is, I look healthy but I'm not. 33 00:01:59,467 --> 00:02:01,077 I always feel like I'm going to 34 00:02:01,121 --> 00:02:03,558 the principal's office for these calls. 35 00:02:04,515 --> 00:02:06,735 I hate doing these calls. 36 00:02:07,605 --> 00:02:09,477 [phone ringing and sighs] 37 00:02:09,955 --> 00:02:12,654 My little stress ball, pancreas. 38 00:02:13,829 --> 00:02:17,963 -Hi, Mary Rose. -Hi Lisa. 39 00:02:18,007 --> 00:02:20,227 You know, there's one thing I want to say. 40 00:02:20,270 --> 00:02:22,142 I wanted to tell you that 41 00:02:22,185 --> 00:02:25,754 I have a little tingling in my heel, in my left heel. 42 00:02:25,797 --> 00:02:28,235 And it's only like when I'm in the shower 43 00:02:28,278 --> 00:02:29,845 and I'm shaving my leg or whatever, 44 00:02:29,888 --> 00:02:32,195 but I've been feeling a bit of tingling and that's, 45 00:02:32,239 --> 00:02:33,675 I'll be honest, it's kind of freaking me out 46 00:02:33,718 --> 00:02:35,938 but I don't know. Like... 47 00:02:35,981 --> 00:02:39,985 Well, it can. The diabetes can be starting to affect 48 00:02:40,029 --> 00:02:41,465 your nervous system. 49 00:02:41,509 --> 00:02:43,467 This could be the beginning of neuropathy. 50 00:02:43,815 --> 00:02:46,209 So, the best thing to do 51 00:02:46,253 --> 00:02:48,124 is get your blood sugars under control. 52 00:02:48,168 --> 00:02:51,475 I mean, you know, I've had Type 1 now 31 years. 53 00:02:51,519 --> 00:02:54,391 And I wasn't always in really tight control. 54 00:02:54,826 --> 00:02:56,437 Yeah. Oh my God. 55 00:02:58,178 --> 00:02:59,962 -[Lisa] Okay. -[Mary Rose] Well... 56 00:03:00,005 --> 00:03:03,313 -I, yeah. -I know, it's hard. 57 00:03:08,753 --> 00:03:10,712 -Yeah. -Well... 58 00:03:10,755 --> 00:03:14,063 We've got today and we can move forward from here. 59 00:03:14,281 --> 00:03:19,373 You know, it's best to face this before it gets real bad, Lisa. 60 00:03:20,983 --> 00:03:24,029 I could never judge you for not being perfect with this, honey 61 00:03:24,073 --> 00:03:26,162 'cause I couldn't do it myself 62 00:03:27,816 --> 00:03:31,123 and I don't, that's why I think you should come see me more 63 00:03:31,167 --> 00:03:33,909 because you can't do it yourself either. 64 00:03:33,952 --> 00:03:35,302 Yeah. 65 00:03:35,780 --> 00:03:38,653 -Bye. -Bye. Thank you. 66 00:03:45,442 --> 00:03:46,704 Hmm. 67 00:03:49,490 --> 00:03:53,363 It's just something I hope that goes away, 68 00:03:53,407 --> 00:03:55,147 if I take better care of myself. 69 00:03:58,542 --> 00:04:03,112 [soft piano music] 70 00:04:05,723 --> 00:04:07,638 It's become a joke in the community 71 00:04:07,682 --> 00:04:11,251 that the cure is always five years away. 72 00:04:12,252 --> 00:04:15,516 Stay strong, the cure is on the horizon. 73 00:04:16,865 --> 00:04:18,562 [phone ringing] 74 00:04:18,606 --> 00:04:22,871 But each year more than 5 million people die from diabetes 75 00:04:22,914 --> 00:04:24,525 waiting for that cure. 76 00:04:25,395 --> 00:04:29,486 If it's so close, why it's taking so long? 77 00:04:31,619 --> 00:04:34,361 We started looking for a biotech company 78 00:04:34,404 --> 00:04:36,145 that was doing something different, 79 00:04:36,537 --> 00:04:38,190 something radical. 80 00:04:39,104 --> 00:04:43,718 Then in 2014, my husband Guy and I heard about a company 81 00:04:44,240 --> 00:04:47,156 that was rethinking how to cure diabetes. 82 00:04:48,897 --> 00:04:52,988 They had engineered stem cells to implant into humans. 83 00:04:54,163 --> 00:04:57,514 We were skeptical but intrigued. 84 00:04:57,775 --> 00:05:01,649 [suspense music] 85 00:05:03,433 --> 00:05:06,349 The first patient got his insulin in 1922. 86 00:05:08,743 --> 00:05:13,008 We cannot be a strong nation unless we are a healthy nation. 87 00:05:13,051 --> 00:05:16,707 And so we must recruit not only men and materials, 88 00:05:17,273 --> 00:05:20,450 but also knowledge and science. 89 00:05:22,278 --> 00:05:24,324 Scientist Cutter in a new medical age 90 00:05:24,367 --> 00:05:25,977 with the monumental reports 91 00:05:26,021 --> 00:05:28,328 that prove the Salk vaccine against crippling polio 92 00:05:28,371 --> 00:05:30,765 to be a sensational success. 93 00:05:32,288 --> 00:05:35,204 Dr. Salk's own child was 1 of the 2 million children 94 00:05:35,247 --> 00:05:36,640 involved in tests of his vaccine. 95 00:05:37,206 --> 00:05:38,816 Tests which have ended for all time, 96 00:05:38,860 --> 00:05:41,428 the threat of one of the world's most vicious diseases. 97 00:05:41,471 --> 00:05:44,648 Measles vaccines have been successfully tested 98 00:05:44,692 --> 00:05:47,216 by thousands of parents who have permitted their children 99 00:05:47,259 --> 00:05:49,131 to participate in the field trial. 100 00:05:50,132 --> 00:05:52,134 Behind it all are tests and research 101 00:05:52,177 --> 00:05:53,875 and years of development and hope. 102 00:05:55,224 --> 00:05:57,748 Do you think that you'll live to see a cure? 103 00:05:57,792 --> 00:05:59,228 No. 104 00:05:59,446 --> 00:06:02,362 Science moves in a way that's not linear. 105 00:06:03,406 --> 00:06:07,367 It can be incremental, punctuated by breakthroughs, 106 00:06:07,410 --> 00:06:08,846 back to incremental. 107 00:06:09,412 --> 00:06:12,763 Is there any guarantee this will actually work? 108 00:06:12,807 --> 00:06:16,506 There is never a guarantee when you're doing a clinical trial. 109 00:06:16,550 --> 00:06:20,118 If there was a guarantee, you wouldn't have to do the trial. 110 00:06:43,794 --> 00:06:46,667 [rolling wheels] 111 00:06:50,497 --> 00:06:56,067 We just submitted our first IND to the FDA in the United States. 112 00:06:57,591 --> 00:07:00,245 And that's an investigative new drug application. 113 00:07:01,769 --> 00:07:05,207 And altogether it's over 8,500 pages. 114 00:07:07,557 --> 00:07:09,951 I'm just going to clear off some space 115 00:07:09,994 --> 00:07:11,561 so that it doesn't look so awful. 116 00:07:11,605 --> 00:07:13,041 Why? No. 117 00:07:16,653 --> 00:07:17,828 Perfect. 118 00:07:17,872 --> 00:07:19,264 For me, it's only the culmination 119 00:07:19,308 --> 00:07:21,049 of a little over three years of work. 120 00:07:21,092 --> 00:07:23,747 But for some of my colleagues, they've been involved in 121 00:07:23,791 --> 00:07:25,314 ViaCyte for over a decade. 122 00:07:25,357 --> 00:07:27,664 and their heart and soul professionally 123 00:07:27,708 --> 00:07:31,799 has gone into this company and our product. 124 00:07:33,061 --> 00:07:34,932 So, this is a mock up 125 00:07:34,976 --> 00:07:37,326 and it doesn't contain an actual device but 126 00:07:37,935 --> 00:07:40,372 Actually let me just take a look, maybe I'm lying to you. 127 00:07:40,416 --> 00:07:42,244 it's easier if I take it out of this package. 128 00:07:43,985 --> 00:07:45,421 Oh, I lied. 129 00:07:45,943 --> 00:07:47,858 So, you can see the implant right in there. 130 00:07:48,293 --> 00:07:49,860 And it contains cells. 131 00:07:50,426 --> 00:07:51,949 That one contains cells right now? 132 00:07:51,993 --> 00:07:53,821 Yeah. 133 00:07:53,864 --> 00:07:56,954 What we're developing is a bio artificial pancreas 134 00:07:56,998 --> 00:07:58,347 that uses stem cells 135 00:07:58,390 --> 00:08:02,046 to potentially cure Type 1 diabetes. 136 00:08:02,569 --> 00:08:04,309 [soft piano music] 137 00:08:04,353 --> 00:08:08,270 It sounds groundbreaking, but diabetes is complicated. 138 00:08:08,531 --> 00:08:09,489 Alright. 139 00:08:11,316 --> 00:08:13,231 It all started with the pancreas, 140 00:08:13,275 --> 00:08:15,886 the ugliest organ in the body. 141 00:08:17,497 --> 00:08:20,717 In Type 1 diabetes, the body attacks itself 142 00:08:20,761 --> 00:08:23,503 and destroys the cells that produce insulin. 143 00:08:25,505 --> 00:08:27,332 And when you don't have insulin, 144 00:08:27,376 --> 00:08:31,032 sugar builds up in the blood and it can't get into the cells. 145 00:08:31,511 --> 00:08:34,426 It's as vital to the body as oxygen. 146 00:08:35,863 --> 00:08:37,995 While people with Type 2 diabetes 147 00:08:38,256 --> 00:08:40,476 have trouble absorbing insulin, 148 00:08:40,520 --> 00:08:44,306 Type 1's don't produce any insulin at all. 149 00:08:45,307 --> 00:08:49,137 Either way, too much sugar in your blood is toxic. 150 00:08:51,008 --> 00:08:54,838 High blood sugars can lead to blindness, kidney failure, 151 00:08:55,230 --> 00:08:57,537 strokes and amputation. 152 00:08:58,755 --> 00:09:02,803 Low blood sugars, and you risk unconsciousness and death. 153 00:09:04,152 --> 00:09:06,458 So, I'm constantly injecting insulin 154 00:09:06,502 --> 00:09:08,939 to control the amount of sugar in my blood. 155 00:09:10,027 --> 00:09:13,074 Normal blood sugars are flat with the odd spike. 156 00:09:14,249 --> 00:09:16,947 My blood sugars look like the Himalayas. 157 00:09:19,820 --> 00:09:23,214 [melodic piano music] 158 00:09:23,650 --> 00:09:24,912 Perfect. 159 00:09:27,392 --> 00:09:30,178 ViaCyte wants to fix this toxic rollercoaster, 160 00:09:31,309 --> 00:09:33,660 program stem cells to make insulin, 161 00:09:34,008 --> 00:09:35,836 put them in a high tech teabag, 162 00:09:36,271 --> 00:09:39,622 implant them into humans and over time, 163 00:09:39,666 --> 00:09:41,755 they'll replace the damaged cells in the body. 164 00:09:41,798 --> 00:09:43,278 Okay Jay, ready? 165 00:09:46,107 --> 00:09:47,456 Seal. 166 00:09:47,499 --> 00:09:50,415 We can do as much testing on the bench 167 00:09:50,459 --> 00:09:52,809 and in animals as we want. 168 00:09:52,853 --> 00:09:56,639 And we still don't know how it'll work in people. 169 00:09:56,987 --> 00:09:58,510 And that's why we're all here 170 00:09:58,728 --> 00:10:00,295 to make it work in people. 171 00:10:03,820 --> 00:10:09,043 Okay, so today was our 30-day clock on the IND. 172 00:10:09,086 --> 00:10:11,567 I was hoping to make this a very suspenseful meeting, 173 00:10:11,611 --> 00:10:14,265 but somehow having bowels of champagne. 174 00:10:14,309 --> 00:10:16,137 And I guess if the answer was bad, 175 00:10:16,180 --> 00:10:17,181 it would've been hard liquor. 176 00:10:17,747 --> 00:10:20,010 [crowd laughing] 177 00:10:20,054 --> 00:10:21,664 There are no hold issues 178 00:10:21,708 --> 00:10:23,535 and the clinical trial may proceed. 179 00:10:24,275 --> 00:10:26,887 [crowd cheering] 180 00:10:29,150 --> 00:10:31,848 [indistinct chatter] 181 00:10:32,893 --> 00:10:34,764 The third or fourth emotion I had, 182 00:10:34,808 --> 00:10:37,158 It was like, "Oh yeah. Now, I can be excited about this." 183 00:10:38,855 --> 00:10:40,770 Been here 12 years. 184 00:10:41,684 --> 00:10:43,207 This is my life's work 185 00:10:43,555 --> 00:10:47,211 to see it come this far and officially go into a patient. 186 00:10:48,691 --> 00:10:49,997 It's amazing. 187 00:10:51,651 --> 00:10:53,870 This is a new frontier. 188 00:10:54,654 --> 00:10:56,960 The FDA is understandably concerned 189 00:10:57,004 --> 00:10:58,527 about the safety risks 190 00:10:58,570 --> 00:11:00,790 associated with any kind of cell therapy, 191 00:11:00,834 --> 00:11:04,664 but they recognize that patients need better treatments. 192 00:11:06,578 --> 00:11:10,365 It takes 10 to 20 years to develop a new drug, 193 00:11:10,844 --> 00:11:14,064 but those are usually drugs that are not that novel. 194 00:11:14,108 --> 00:11:16,501 It's a pill, you eat it. Everyone knows how to do that. 195 00:11:17,851 --> 00:11:19,461 This is extremely novel. 196 00:11:19,504 --> 00:11:20,680 Nightie Night. 197 00:11:20,723 --> 00:11:23,204 [suspense music] 198 00:11:28,122 --> 00:11:29,776 I don't think anyone knew 199 00:11:29,819 --> 00:11:32,082 how long this trial was going to take. 200 00:11:33,170 --> 00:11:34,737 We were still in Phase 1, 201 00:11:34,781 --> 00:11:37,653 where scientists test if their product is safe 202 00:11:37,697 --> 00:11:39,742 and tolerated by humans. 203 00:11:39,786 --> 00:11:42,658 I am sure you were hoping we would have definitive answers 204 00:11:42,702 --> 00:11:44,181 for you to film by now. 205 00:11:44,225 --> 00:11:45,705 Welcome to the exciting, 206 00:11:45,748 --> 00:11:48,620 but often frustrating world of biotechnology. 207 00:11:51,275 --> 00:11:53,016 It's a critical stage, 208 00:11:53,060 --> 00:11:55,453 but it doesn't show if the product is working. 209 00:11:57,064 --> 00:11:59,588 [soft music] 210 00:11:59,631 --> 00:12:02,504 Clinical studies like this are set up in phases 211 00:12:02,547 --> 00:12:03,853 for very good reason. 212 00:12:04,593 --> 00:12:07,335 The first phase is designed to determine 213 00:12:07,378 --> 00:12:09,816 basic safety tolerance 214 00:12:09,859 --> 00:12:11,643 and not put a whole bunch of patients at risk 215 00:12:11,687 --> 00:12:13,733 without understanding that it's safe first. 216 00:12:15,691 --> 00:12:17,824 The second phase is the most exciting, 217 00:12:17,867 --> 00:12:19,913 because that's where you get the data. 218 00:12:19,956 --> 00:12:21,001 The proof of concept. 219 00:12:22,306 --> 00:12:23,655 Two, three. 220 00:12:24,656 --> 00:12:27,355 Then the moment we'd all been waiting for. 221 00:12:27,398 --> 00:12:30,140 The FDA gave them the green light 222 00:12:30,184 --> 00:12:32,142 to move to Phase 2 of the trial. 223 00:12:33,013 --> 00:12:35,232 It was finally time to see 224 00:12:35,276 --> 00:12:37,408 if the cells could work in people. 225 00:12:37,757 --> 00:12:40,890 [suspense music] 226 00:12:42,152 --> 00:12:43,501 How much is riding on this? 227 00:12:44,459 --> 00:12:45,765 Everything. 228 00:12:47,767 --> 00:12:49,507 Everything, sorry. 229 00:12:56,036 --> 00:12:59,082 [melodic music] 230 00:13:01,519 --> 00:13:05,219 ViaCyte opened 7 trial sites in the US and Canada. 231 00:13:07,134 --> 00:13:09,658 Including one at the University of Minnesota. 232 00:13:12,487 --> 00:13:14,489 And that's where we met patient one, 233 00:13:14,881 --> 00:13:16,186 Maren. 234 00:13:17,579 --> 00:13:18,928 [glucometer beeping] 235 00:13:34,335 --> 00:13:39,035 [hair brushing] 236 00:13:42,865 --> 00:13:44,301 Want to come downstairs? 237 00:13:45,215 --> 00:13:46,477 Come on. 238 00:13:46,521 --> 00:13:49,611 [key chains dangling] 239 00:13:50,438 --> 00:13:52,962 [car engine revving] 240 00:13:54,094 --> 00:13:56,444 When did you give me insulin? 241 00:13:56,487 --> 00:13:59,621 3:30, more or less. 242 00:14:01,841 --> 00:14:04,408 [soft piano music] 243 00:14:04,452 --> 00:14:05,888 From the time I was very little, 244 00:14:05,932 --> 00:14:08,456 I said that I would always be first in line. 245 00:14:08,848 --> 00:14:12,503 If something came up or there was the opportunity for a cure. 246 00:14:15,463 --> 00:14:16,943 Nervous? 247 00:14:18,205 --> 00:14:19,728 There's a lot of unknowns 248 00:14:19,771 --> 00:14:22,035 and I think it's the unknowns, that are terrifying. 249 00:14:23,950 --> 00:14:25,821 [melodic music] 250 00:14:27,997 --> 00:14:30,260 I'd like to think I'm a pioneer. 251 00:14:31,261 --> 00:14:33,916 When you read in textbooks 50 years later, 252 00:14:33,960 --> 00:14:35,178 she was the first. 253 00:14:36,310 --> 00:14:39,530 She was the first one to try it and it worked. 254 00:14:39,574 --> 00:14:42,185 [melodic music] 255 00:14:42,229 --> 00:14:45,275 [indistinct chatter] 256 00:14:46,929 --> 00:14:48,191 This is you. 257 00:14:48,844 --> 00:14:50,063 It's a huge deal. 258 00:14:51,542 --> 00:14:54,632 This can impact millions of diabetics. 259 00:14:55,590 --> 00:14:58,419 And it's me, it's me on that operating table. 260 00:14:58,462 --> 00:14:59,986 This way. 261 00:15:00,029 --> 00:15:01,770 We're the first door on the left here. 262 00:15:03,032 --> 00:15:06,079 Hi Maren, welcome. 263 00:15:07,776 --> 00:15:13,347 [suspense music] 264 00:15:25,098 --> 00:15:27,535 -So, it's done. -It's done. 265 00:15:27,578 --> 00:15:29,232 It's great. It went really, really well. 266 00:15:29,276 --> 00:15:31,495 She's in the main O.R. waking up area 267 00:15:31,539 --> 00:15:33,106 where they really watch airway and everything. 268 00:15:33,149 --> 00:15:34,585 And then once they deem her to be safe, 269 00:15:34,629 --> 00:15:36,239 then she'll come here for a little bit more time 270 00:15:36,283 --> 00:15:37,675 and they'll be checking her sugars 271 00:15:37,719 --> 00:15:39,286 and doing all those other things. 272 00:15:39,329 --> 00:15:40,461 And then you guys can be with her here. 273 00:15:40,504 --> 00:15:42,115 -Perfect. -Alright, thank you. 274 00:15:44,030 --> 00:15:45,727 Take a deep breath. Huh? 275 00:15:47,381 --> 00:15:51,037 32 years in the waiting. It's been a long time. 276 00:15:52,516 --> 00:15:54,562 Hoped and prayed for this for a long time. 277 00:15:55,780 --> 00:15:58,609 [indistinct chatter] 278 00:16:01,569 --> 00:16:03,179 Oh yeah. These ones look great. 279 00:16:03,223 --> 00:16:04,572 -They don't even hurt at all. -Yeah. 280 00:16:04,615 --> 00:16:06,530 They're barely even bruised around there. 281 00:16:06,574 --> 00:16:08,141 -Those don't hurt at all. -Yeah. 282 00:16:08,184 --> 00:16:10,578 Other than that, it's sore down here. 283 00:16:10,621 --> 00:16:12,406 -Yeah. -Right in this area. 284 00:16:12,449 --> 00:16:16,149 -You have such art on your arm. -Still right now. 285 00:16:18,020 --> 00:16:20,980 10 pods were implanted into Maren's body. 286 00:16:21,502 --> 00:16:24,418 Six in her arm and four in her side. 287 00:16:24,461 --> 00:16:25,810 Great. 288 00:16:26,637 --> 00:16:29,901 Every few weeks, one of her pods will be removed 289 00:16:29,945 --> 00:16:33,383 to see if the cells are surviving and producing insulin. 290 00:16:33,427 --> 00:16:35,037 Yeah, I think sometimes the hardest part 291 00:16:35,081 --> 00:16:36,473 is getting used to the medications. 292 00:16:36,734 --> 00:16:38,432 I really do. 293 00:16:38,475 --> 00:16:40,042 It's sore but the pain isn't that bad. 294 00:16:40,086 --> 00:16:41,826 It's sore but it's not the pain. 295 00:16:42,523 --> 00:16:46,048 We'll be continuing to monitor blood tests 296 00:16:46,092 --> 00:16:48,007 for evidence of insulin production. 297 00:16:48,529 --> 00:16:52,185 And I'm sure Cathy will text you or call you 298 00:16:52,228 --> 00:16:55,536 to make sure that it got done. So, yeah. 299 00:16:56,102 --> 00:16:57,755 -All right. Good. -Thank you. 300 00:16:57,799 --> 00:17:00,149 All right, I'll let you go do the hard work here, Cathy. 301 00:17:00,193 --> 00:17:03,022 -Yeah. -And I'll see you next week. 302 00:17:03,065 --> 00:17:05,372 Alright, sounds good. Thank you. Bye. 303 00:17:08,984 --> 00:17:11,421 I was diagnosed with diabetes at the age of two. 304 00:17:11,943 --> 00:17:13,771 I don't know any other way. 305 00:17:13,815 --> 00:17:17,036 Living a normal life to me is living life as a diabetic. 306 00:17:19,560 --> 00:17:22,998 I have some extreme lows which caused me to have seizures. 307 00:17:24,739 --> 00:17:28,482 You're so terrified that you're going to go so low 308 00:17:28,525 --> 00:17:30,310 or you're going to pass out 309 00:17:30,353 --> 00:17:32,007 and your kids are going to find you seizing on the floor. 310 00:17:32,660 --> 00:17:34,053 Just the sweat, 311 00:17:34,096 --> 00:17:35,576 just the dripping and the sweat 312 00:17:35,619 --> 00:17:38,927 and the tremors and the shaking and the fear. 313 00:17:38,970 --> 00:17:40,581 I mean just the fear, 314 00:17:40,624 --> 00:17:43,279 the fear of the low blood sugars. 315 00:17:44,019 --> 00:17:46,282 You can feel your body shutting down 316 00:17:46,326 --> 00:17:47,936 and you've got to stop it. 317 00:17:49,459 --> 00:17:52,680 [breaking wind] 318 00:17:56,205 --> 00:17:59,687 T, Z, Y, something, something L. 319 00:18:00,166 --> 00:18:01,819 And then blink a couple times. 320 00:18:01,863 --> 00:18:03,517 Can you pick out anything below that? 321 00:18:03,865 --> 00:18:08,478 T, Z V, E, C, L. 322 00:18:08,522 --> 00:18:10,132 Go ahead and take your glasses off. 323 00:18:10,176 --> 00:18:11,046 I want you to look straight ahead towards 324 00:18:11,090 --> 00:18:12,526 the end of the room. 325 00:18:13,483 --> 00:18:15,137 And if a light gets bright, you can look up. 326 00:18:15,181 --> 00:18:16,399 Okay. 327 00:18:18,097 --> 00:18:22,013 When I was younger, my family with all their good intentions 328 00:18:22,057 --> 00:18:23,363 they'd tell me things like, 329 00:18:23,406 --> 00:18:24,581 "If you don't check your blood sugar 330 00:18:24,625 --> 00:18:27,018 you're going to loose your foot" 331 00:18:27,062 --> 00:18:28,498 And you know, I'm just like, 332 00:18:28,542 --> 00:18:30,239 "Okay, I'm going to lose my feet." 333 00:18:32,154 --> 00:18:36,245 And that would cause depression, fear, 334 00:18:38,334 --> 00:18:40,162 and a lot of the times, 335 00:18:40,206 --> 00:18:42,164 it made me feel like I just want to give up. 336 00:18:42,208 --> 00:18:43,731 And I have, 337 00:18:43,774 --> 00:18:46,386 I've spent years not taking care of my disease. 338 00:18:46,864 --> 00:18:48,127 Just like, 339 00:18:49,780 --> 00:18:51,042 "Fuck it." 340 00:18:57,005 --> 00:18:58,920 My dad and me are the only two people, 341 00:18:58,963 --> 00:19:00,617 with diabetes that I ever knew. 342 00:19:02,271 --> 00:19:04,969 He was legally blind by the time he was 30. 343 00:19:08,886 --> 00:19:10,453 I'm going blind. 344 00:19:19,680 --> 00:19:21,899 [car engine revving] 345 00:19:24,119 --> 00:19:25,251 It's an apple orchard. 346 00:19:25,294 --> 00:19:26,687 Apple orchard. 347 00:19:26,730 --> 00:19:27,862 [child babbling] 348 00:19:27,905 --> 00:19:30,299 What? Oh. 349 00:19:32,867 --> 00:19:34,912 Come on ladies, let's go find a pumpkin. 350 00:19:38,133 --> 00:19:39,743 We're talking about my life here. 351 00:19:39,787 --> 00:19:42,355 And I'm not afraid of death, but I'm here. 352 00:19:42,398 --> 00:19:44,226 I need to be here for my daughter. 353 00:19:45,227 --> 00:19:46,837 That's what this is about. 354 00:19:47,273 --> 00:19:49,449 Well, come here. Let's see pumpkin. 355 00:19:49,492 --> 00:19:51,015 Quick, quick, there. 356 00:19:51,059 --> 00:19:52,495 And it's not just because 357 00:19:52,539 --> 00:19:54,280 she's going to be in this world alone. 358 00:19:54,323 --> 00:19:56,325 I want to see her fucking grow up. 359 00:19:57,239 --> 00:20:00,373 I don't want to abandon her. 360 00:20:01,156 --> 00:20:03,071 That's the worst feeling on earth. 361 00:20:05,552 --> 00:20:09,947 [melodic piano music] 362 00:20:14,822 --> 00:20:18,826 So, then this talks about the number of participants here. 363 00:20:18,869 --> 00:20:20,610 And so there's a site in Canada, 364 00:20:20,654 --> 00:20:23,134 and right now there's two sites in the United States. 365 00:20:23,178 --> 00:20:24,353 And there'll probably be a few more 366 00:20:24,397 --> 00:20:26,355 that are added over time. 367 00:20:26,399 --> 00:20:28,270 This part talks about the cells 368 00:20:28,314 --> 00:20:29,793 that are actually being tested 369 00:20:29,837 --> 00:20:32,883 and what the cells are, is they're human cells. 370 00:20:32,927 --> 00:20:34,320 So, they're actually derived 371 00:20:34,363 --> 00:20:36,278 from an embryonic stem cell source. 372 00:20:36,322 --> 00:20:38,498 So it's a embryo that was going to be 373 00:20:38,541 --> 00:20:40,326 disposed of from in-vitro fertilization. 374 00:20:40,369 --> 00:20:41,762 Okay. 375 00:20:41,805 --> 00:20:45,461 We don't expect them in that first month or two 376 00:20:45,505 --> 00:20:47,811 to actually do anything functionally yet, 377 00:20:47,855 --> 00:20:50,423 because we do know that they need time to mature 378 00:20:50,466 --> 00:20:51,815 to make insulin. 379 00:20:51,859 --> 00:20:53,208 -Sure. -Okay? 380 00:20:54,340 --> 00:20:56,298 Remind me, when were you diagnosed? 381 00:20:56,342 --> 00:20:57,647 -I was 11 years old. -11 Years old? 382 00:20:57,691 --> 00:20:58,953 -Yeah. -Okay. 383 00:20:58,996 --> 00:21:00,911 About how many times in the past year 384 00:21:00,955 --> 00:21:03,436 do you think you've been so out of it, mentally or physically 385 00:21:03,479 --> 00:21:05,220 that you wouldn't have been able to treat yourself, 386 00:21:05,264 --> 00:21:06,700 you need someone to help treat you? 387 00:21:06,743 --> 00:21:10,530 Gosh, I'd say at probably about 10, at least. 388 00:21:10,573 --> 00:21:12,532 -About 10 in the past years. -At least, yeah. 389 00:21:12,575 --> 00:21:15,883 I get like confusion. I don't know what to do. 390 00:21:15,926 --> 00:21:18,538 I get panicky and then I'll over-treat. 391 00:21:18,581 --> 00:21:21,454 So, then I have to deal with that. 392 00:21:21,497 --> 00:21:24,283 Well, and then when he gets sick, 393 00:21:24,326 --> 00:21:26,937 he ends up so much worse 394 00:21:26,981 --> 00:21:30,376 because the cold or the flu he has 395 00:21:30,419 --> 00:21:32,943 is making his blood sugar all over the place. 396 00:21:33,727 --> 00:21:36,120 Yeah, he spent four days in the hospital 397 00:21:36,164 --> 00:21:37,557 and with DKA and pneumonia 398 00:21:37,600 --> 00:21:38,775 -And pneumonia. -Yeah. 399 00:21:38,819 --> 00:21:43,084 I mean, I resent my disease. 400 00:21:44,303 --> 00:21:45,565 I really want... 401 00:21:47,088 --> 00:21:48,568 This to work. 402 00:21:50,526 --> 00:21:52,572 I completely get that. Yep. 403 00:21:54,443 --> 00:21:56,053 Do you want a minute? or do you want to- 404 00:21:56,097 --> 00:21:57,533 -No. -Go through this still? 405 00:21:57,577 --> 00:21:59,318 All right. You sure? Okay. 406 00:22:00,928 --> 00:22:03,017 [phone ringing] 407 00:22:05,367 --> 00:22:06,629 How you doing? 408 00:22:10,938 --> 00:22:12,287 It's a lot. 409 00:22:15,551 --> 00:22:16,726 Okay. 410 00:22:17,292 --> 00:22:18,598 You okay? 411 00:22:35,049 --> 00:22:37,573 [soft music] 412 00:22:38,269 --> 00:22:40,837 Let me take a look at your temperature under your tongue. 413 00:22:41,882 --> 00:22:45,668 [scale beeping] 414 00:22:47,061 --> 00:22:48,410 I think you're good. 415 00:22:50,107 --> 00:22:51,544 Okay, you can step away. 416 00:22:57,376 --> 00:22:59,421 Okay, you're going to feel a little poke. 417 00:22:59,943 --> 00:23:03,120 [soft music] 418 00:23:07,516 --> 00:23:08,778 [knock on door] 419 00:23:09,475 --> 00:23:11,085 Hi, this is Maren. 420 00:23:11,128 --> 00:23:12,608 -I'm Greg. -Hi, nice to meet you. 421 00:23:12,652 --> 00:23:14,218 -Maren? -Maren, yep. 422 00:23:14,262 --> 00:23:15,916 -Nice to meet you. -I'm Greg. 423 00:23:15,959 --> 00:23:17,396 Are you overwhelmed? 424 00:23:17,439 --> 00:23:19,310 -A little bit. -A little bit. 425 00:23:19,659 --> 00:23:21,138 Well, they're awesome here. 426 00:23:21,182 --> 00:23:22,531 They will take good care of you, I promise. 427 00:23:22,575 --> 00:23:25,969 So, you probably have a ton of questions. 428 00:23:26,013 --> 00:23:28,102 I had a ton of questions and I was first. 429 00:23:28,145 --> 00:23:31,105 -Yeah. -So, ask away. 430 00:23:31,497 --> 00:23:35,762 Well, so, where did they put all that? 431 00:23:36,632 --> 00:23:38,504 And those are the scars that you got? 432 00:23:38,547 --> 00:23:41,376 Yep, you can feel them, you can feel them inside. 433 00:23:41,420 --> 00:23:43,160 -Do you mind? -Yeah, go for it. 434 00:23:44,248 --> 00:23:46,860 -Oh. Okay! -Interesting. 435 00:23:46,903 --> 00:23:49,906 So there's one, two, three, four, five, six, 436 00:23:50,516 --> 00:23:53,693 and then I have four more right here. 437 00:23:54,084 --> 00:23:55,695 Hmm. Okay. 438 00:23:56,260 --> 00:23:58,567 It's a very surreal feeling 439 00:23:58,611 --> 00:24:01,135 that you can't describe unless, you know. 440 00:24:01,178 --> 00:24:03,920 This whole thing's been a surreal ride for me. 441 00:24:04,181 --> 00:24:05,792 I'm still just, ah. 442 00:24:05,835 --> 00:24:08,229 And even the day of, 443 00:24:08,534 --> 00:24:10,057 they're wheeling me back to the O.R., 444 00:24:10,100 --> 00:24:11,450 I was laying there and I'm going, 445 00:24:11,493 --> 00:24:12,712 "Oh my God, I don't know if I can do this, 446 00:24:12,755 --> 00:24:14,148 I don't know if I can do this." 447 00:24:14,191 --> 00:24:15,279 'Cause they haven't done it. 448 00:24:16,672 --> 00:24:19,675 And I'm thinking to myself going, "Can I do this?" 449 00:24:19,719 --> 00:24:21,068 Wow. 450 00:24:22,417 --> 00:24:23,897 Is it affecting you? 451 00:24:23,940 --> 00:24:27,422 -You know, technically, no. -Yeah. 452 00:24:27,466 --> 00:24:29,772 But I think there's definitely some changes 453 00:24:29,816 --> 00:24:31,078 going on in my body. 454 00:24:31,121 --> 00:24:32,906 I can't exactly tell what they are. 455 00:24:33,472 --> 00:24:34,951 And then at the end of the study, 456 00:24:34,995 --> 00:24:36,475 they take them out, it's like, 457 00:24:36,910 --> 00:24:38,738 you know what I mean? 458 00:24:38,781 --> 00:24:40,435 I don't know what that's going to do to me psychologically. 459 00:24:40,479 --> 00:24:42,132 Well, it is. It'll mess with you. 460 00:24:42,176 --> 00:24:43,960 I guarantee it'll mess with you. 461 00:24:44,004 --> 00:24:47,442 And they're taking one out in a week and a half already. 462 00:24:47,486 --> 00:24:50,576 And I don't want them to. 463 00:24:50,619 --> 00:24:52,229 - Right. -You know what I mean? 464 00:24:52,273 --> 00:24:54,014 'Cause I want to see if it's going to work, 465 00:24:54,057 --> 00:24:55,842 but yet part of science 466 00:24:55,885 --> 00:24:58,497 and I'm trying to come to grips with on my own is, 467 00:24:59,062 --> 00:25:00,673 is it even working? 468 00:25:00,716 --> 00:25:03,066 I've told people it's like winning the lottery. 469 00:25:03,110 --> 00:25:05,982 Because if it works, it's like winning the lottery. 470 00:25:06,026 --> 00:25:07,462 Exactly. 471 00:25:07,506 --> 00:25:09,856 I'd rather have this than win the lottery. 472 00:25:11,901 --> 00:25:16,079 [soft music] 473 00:25:55,118 --> 00:26:01,516 [monitor beeping] 474 00:26:09,785 --> 00:26:13,354 [soft music] 475 00:26:16,009 --> 00:26:19,142 There are two worlds in a clinical trial. 476 00:26:20,709 --> 00:26:23,233 Inside the lives of the patients 477 00:26:23,277 --> 00:26:26,149 who are putting themselves on the line to be first 478 00:26:29,370 --> 00:26:31,677 and inside the labs of the researchers, 479 00:26:32,155 --> 00:26:36,159 who want to transform patient hope into reality. 480 00:26:42,035 --> 00:26:44,820 The two worlds create a dynamic universe 481 00:26:45,386 --> 00:26:47,170 yet they aren't allowed to meet. 482 00:26:50,478 --> 00:26:53,916 There's a firewall between the patients and researchers 483 00:26:54,177 --> 00:26:56,397 to ensure the study remains objective. 484 00:26:58,486 --> 00:27:01,620 We became the bridge between these two worlds. 485 00:27:05,406 --> 00:27:08,322 We learned that whatever was revealed to us, 486 00:27:08,365 --> 00:27:10,193 could never be revealed to the other, 487 00:27:12,718 --> 00:27:15,285 including the question on everyone's minds. 488 00:27:16,504 --> 00:27:17,897 Is it working? 489 00:27:29,256 --> 00:27:31,040 Was that Tamara? Hi Tamara. 490 00:27:31,084 --> 00:27:32,651 -Hi Lisa. -How are you? 491 00:27:37,003 --> 00:27:38,787 -[sighs] -Okay guys. 492 00:27:41,834 --> 00:27:45,141 [keyboard clattering] 493 00:27:46,099 --> 00:27:48,754 We get email all the time. 494 00:27:48,797 --> 00:27:50,756 These come from all around the world. 495 00:27:51,234 --> 00:27:53,846 "Hi, I have diabetes type 1 496 00:27:53,889 --> 00:27:55,674 and I would like to know if there's any chance 497 00:27:55,717 --> 00:27:58,198 to participate as a volunteer living here in Brazil. 498 00:27:58,241 --> 00:28:00,113 Thanks from Paolo." 499 00:28:01,114 --> 00:28:02,637 Here's another one. 500 00:28:02,681 --> 00:28:05,640 "Hi, our 15-year old son was diagnosed with 501 00:28:05,684 --> 00:28:07,555 type 1 diabetes this week." 502 00:28:07,947 --> 00:28:09,383 Wow. 503 00:28:09,775 --> 00:28:12,778 This is an email from Mexico. 504 00:28:13,300 --> 00:28:15,868 "Hello, yesterday, my six-years old Paulina 505 00:28:15,911 --> 00:28:18,871 was diagnostic diabetes type 1, insulin independent. 506 00:28:19,480 --> 00:28:21,743 She had a perfect health till yesterday 507 00:28:21,787 --> 00:28:23,963 that my little girl was rushed into the emergency room 508 00:28:24,006 --> 00:28:25,660 with a 480 glucose level. 509 00:28:26,574 --> 00:28:29,751 She's so cheerful and all day, every day is singing 510 00:28:29,795 --> 00:28:31,710 every song she hears and 511 00:28:32,493 --> 00:28:34,843 know she is attached to a machine 512 00:28:34,887 --> 00:28:38,020 that has to introduce insulin to her little hand and her body." 513 00:28:38,717 --> 00:28:41,720 Capital letters, "I don't want that life for her." 514 00:28:43,983 --> 00:28:47,116 Yes, so these keep 515 00:28:49,989 --> 00:28:51,381 keep things in perspective. 516 00:28:53,601 --> 00:28:54,994 Just goes on and on. 517 00:29:03,393 --> 00:29:09,225 [soft piano music] 518 00:29:31,291 --> 00:29:33,032 I have two biological children 519 00:29:33,075 --> 00:29:35,686 and four adopted children. 520 00:29:36,731 --> 00:29:38,646 Is your phone working after you spilled on it? 521 00:29:38,689 --> 00:29:40,343 Yeah. 522 00:29:40,387 --> 00:29:42,519 I'll try calling you quick and see if it makes the noise. 523 00:29:42,563 --> 00:29:44,739 -My phone's over here. -No, don't answer. 524 00:29:44,783 --> 00:29:47,524 When I gave birth to Katelyn, I had a seizure. 525 00:29:47,568 --> 00:29:49,048 That was the first seizure I had had. 526 00:29:49,091 --> 00:29:50,397 [phone ringing] 527 00:29:50,440 --> 00:29:52,051 -Yeah, it worked. -Okay. 528 00:29:52,660 --> 00:29:54,270 Okay. Bye Kate. 529 00:29:54,314 --> 00:29:55,924 -Bye. -See ya. 530 00:29:55,968 --> 00:29:57,578 We'll see you at church, okay? 531 00:29:57,621 --> 00:29:59,014 Bye. Katelyn. Love you. 532 00:29:59,493 --> 00:30:00,799 I almost died. 533 00:30:01,538 --> 00:30:04,759 I almost left my daughter without a mom 534 00:30:05,281 --> 00:30:06,805 and my husband without a wife. 535 00:30:08,589 --> 00:30:11,374 The second seizure I had was after the birth of Andrew, 536 00:30:11,418 --> 00:30:13,246 which was actually in the hospital. 537 00:30:15,291 --> 00:30:16,815 So, we made the determination that 538 00:30:16,858 --> 00:30:19,034 we were done having biological children at that point. 539 00:30:19,600 --> 00:30:20,644 Go pack lunch. 540 00:30:21,297 --> 00:30:22,951 Cold lunch, you mean? 541 00:30:22,995 --> 00:30:24,083 Yep. Cold lunch. 542 00:30:24,953 --> 00:30:26,825 Get your shoes on. You got backpack? 543 00:30:27,260 --> 00:30:28,827 I want to go. 544 00:30:33,614 --> 00:30:36,573 I think living with a disease, 545 00:30:36,617 --> 00:30:39,925 it creates who you are and it makes you more accepting 546 00:30:39,968 --> 00:30:42,101 of other people in their unique situations. 547 00:30:42,362 --> 00:30:44,059 [soft piano music] 548 00:30:44,103 --> 00:30:46,192 I don't know why her tales moping. 549 00:30:50,283 --> 00:30:51,850 Guess what's for dinner? 550 00:30:52,720 --> 00:30:54,113 Pizza night. 551 00:30:54,156 --> 00:30:55,592 Mom, are you going to come? 552 00:30:55,636 --> 00:30:56,811 -To church? -Yeah. 553 00:30:57,246 --> 00:30:59,509 -I'll help Merlie again. -Okay. 554 00:30:59,814 --> 00:31:01,424 I do the arithmetic in my head. 555 00:31:02,208 --> 00:31:04,993 I want to see them graduate. I want to see them get married. 556 00:31:06,734 --> 00:31:09,911 I set personal goals for myself. What I want to see them reach. 557 00:31:11,739 --> 00:31:15,177 [engine roaring] 558 00:31:17,310 --> 00:31:21,705 [soft piano music] 559 00:31:31,672 --> 00:31:33,804 I thought they were going to get an IV in, 560 00:31:33,848 --> 00:31:35,371 but I don't know. 561 00:31:35,415 --> 00:31:38,070 I don't think so. We're doing a blood draw today. 562 00:31:39,636 --> 00:31:41,464 [phone vibrating] 563 00:31:45,599 --> 00:31:48,907 -Yeah, we got it. -First try too. 564 00:31:50,430 --> 00:31:51,953 Are you showing them your sugars? 565 00:31:51,997 --> 00:31:55,696 No, I have no explanation. 566 00:31:55,739 --> 00:31:57,393 I know. 567 00:31:57,437 --> 00:32:01,484 The average glucose dropped from 164 to 140 568 00:32:01,528 --> 00:32:05,532 -164 to 140 was your average. -To 140. 569 00:32:05,575 --> 00:32:07,403 That's really good. 570 00:32:07,969 --> 00:32:09,579 -Here was your surgery day. -Yeah. 571 00:32:09,623 --> 00:32:11,930 And I wasn't feeling real great those couple days 572 00:32:11,973 --> 00:32:15,150 -That is not a surprise, there. -But-- 573 00:32:15,194 --> 00:32:17,587 But it really hasn't gone much up since then 574 00:32:17,631 --> 00:32:20,199 and it's actually gone down. 575 00:32:20,808 --> 00:32:21,983 That's interesting. 576 00:32:24,725 --> 00:32:26,074 Let's see if the doctor-- 577 00:32:26,118 --> 00:32:27,902 Okay, so here we go. 578 00:32:27,946 --> 00:32:29,599 Look what happened on its own? 579 00:32:30,339 --> 00:32:33,081 My blood sugars went up and now it's plateauing. 580 00:32:33,473 --> 00:32:36,128 That's, I think probably 200 points less 581 00:32:36,171 --> 00:32:37,781 than what it got to last time. 582 00:32:38,565 --> 00:32:40,741 Well, I'm anxious to get the results now 583 00:32:40,784 --> 00:32:42,395 'cause I'm curious, I'm very curious. 584 00:32:42,438 --> 00:32:43,918 I think everybody is. 585 00:32:43,962 --> 00:32:46,877 It's not really good to speculate that much, 586 00:32:46,921 --> 00:32:50,446 but it should be too early for yourselves to be working. 587 00:32:50,490 --> 00:32:52,622 I know it is. That's what they said. 588 00:32:53,145 --> 00:32:55,321 Whatever it is, something's working. 589 00:32:57,410 --> 00:33:01,240 [Latin music] 590 00:33:06,375 --> 00:33:09,291 No, no. 'Cause it had only went up to like 260 591 00:33:09,335 --> 00:33:10,901 and then it went down on its own. 592 00:33:11,467 --> 00:33:13,339 It's on its way down right now. 593 00:33:13,382 --> 00:33:15,558 I didn't dose. 594 00:33:20,041 --> 00:33:23,566 Yeah. I mean, you can't really argue it at this point. 595 00:33:23,610 --> 00:33:25,916 I mean, it doesn't do that on its own. 596 00:33:25,960 --> 00:33:27,657 You know what I mean? For a diabetic? 597 00:33:30,878 --> 00:33:32,140 Right, so. 598 00:33:36,188 --> 00:33:39,843 Right. Not fully. Three weeks today. 599 00:33:40,192 --> 00:33:41,845 Three weeks today. Yup. 600 00:33:43,108 --> 00:33:44,544 You guys want to bite of this? 601 00:33:44,587 --> 00:33:46,241 Andrew, you want to share it with me? 602 00:33:46,285 --> 00:33:48,374 -What is it? -I don't like the texture. 603 00:33:50,071 --> 00:33:51,551 I think I'm blind. 604 00:33:51,594 --> 00:33:54,467 -Does it work? -Yep. 605 00:33:54,728 --> 00:33:55,990 Okay. 606 00:33:57,861 --> 00:33:59,037 That's good. 607 00:34:00,125 --> 00:34:03,041 [winds] 608 00:34:03,867 --> 00:34:07,871 [car engine running] 609 00:34:10,700 --> 00:34:12,398 Six weeks into the trial, 610 00:34:12,441 --> 00:34:14,661 Maren was telling me how good she felt 611 00:34:14,704 --> 00:34:17,490 and that her blood sugars had never looked better. 612 00:34:20,145 --> 00:34:22,538 But, the researchers were telling me something different. 613 00:34:23,800 --> 00:34:26,499 That it was too early for her cells to be working. 614 00:34:28,675 --> 00:34:30,068 Gotta get them on the phone now. 615 00:34:30,111 --> 00:34:31,417 I don't know your sign in. 616 00:34:31,460 --> 00:34:33,723 I was now straddling the firewall 617 00:34:33,767 --> 00:34:36,291 that separated the patients from the researchers. 618 00:34:36,335 --> 00:34:38,119 [phone ringing] 619 00:34:38,163 --> 00:34:39,729 So I called Howard Foyt, 620 00:34:39,773 --> 00:34:42,645 who's in charge of clinical trials at ViaCyte. 621 00:34:43,777 --> 00:34:45,518 Hi Howard, it's Lisa. 622 00:34:45,561 --> 00:34:48,738 He became my bridge to what was happening in the lab. 623 00:34:48,782 --> 00:34:52,916 So, can I ask you as a patient with type 1, me? 624 00:34:52,960 --> 00:34:55,876 If I was doing all the work 625 00:34:55,919 --> 00:34:59,793 testing my sugars, uploading, going in three times a week 626 00:34:59,836 --> 00:35:03,013 to my uni to get tested, all that jazz 627 00:35:03,057 --> 00:35:05,103 and I was seeing some good results, 628 00:35:06,016 --> 00:35:08,584 do you think and you weren't told anything, 629 00:35:08,628 --> 00:35:11,283 do you think that emotionally that would be hard? 630 00:35:11,718 --> 00:35:14,199 Because they're seeking answers. 631 00:35:14,242 --> 00:35:19,508 The patients are so desperate to know what's happening. 632 00:35:19,552 --> 00:35:22,163 I see way what you are challenging. 633 00:35:23,033 --> 00:35:25,993 because they have a lot of hopes and aspirations 634 00:35:26,036 --> 00:35:28,648 that this therapy is going to help them. 635 00:35:28,691 --> 00:35:30,345 And so, 636 00:35:30,389 --> 00:35:33,566 yes, I can see where it would be frustrating, 637 00:35:33,609 --> 00:35:35,263 but at the same time, 638 00:35:35,307 --> 00:35:38,223 they understand that this is clinical research. 639 00:35:38,745 --> 00:35:40,747 It's a convoluted protocol. 640 00:35:40,790 --> 00:35:43,402 I mean, it's one of the most complicated studies 641 00:35:43,445 --> 00:35:45,404 I have ever been involved with. 642 00:35:45,665 --> 00:35:47,710 I'm the first one to admit that. 643 00:35:48,494 --> 00:35:50,496 Have you seen any C-peptide levels yet? 644 00:35:50,974 --> 00:35:53,760 I cannot comment on that and you know that. 645 00:35:56,850 --> 00:35:58,156 Oh, perfect timing. 646 00:35:58,199 --> 00:36:00,810 -[Lisa laughing] -[Howard] Bye. 647 00:36:01,376 --> 00:36:04,379 [soft music] 648 00:36:04,640 --> 00:36:08,514 C-peptide levels are the holy grail of this study. 649 00:36:09,123 --> 00:36:12,909 They mean the cells are producing insulin in patients. 650 00:36:13,475 --> 00:36:16,435 [suspense music] 651 00:36:18,350 --> 00:36:21,135 [elevator dings] 652 00:36:24,747 --> 00:36:26,445 Greg, is it going to bother you too much 653 00:36:26,488 --> 00:36:27,924 if I turn lights on here? 654 00:36:27,968 --> 00:36:29,056 -No. -Okay. 655 00:36:30,927 --> 00:36:32,190 There we go. 656 00:36:33,843 --> 00:36:35,410 So, it sounds a lot worse today than you feel over the weekend. 657 00:36:38,457 --> 00:36:41,286 So like Saturday it was mostly like sore throat, right? 658 00:36:44,332 --> 00:36:48,858 Okay. So, one of those infections that 659 00:36:49,772 --> 00:36:52,514 could be something that you would've gotten anyway 660 00:36:52,558 --> 00:36:55,169 if you weren't on the drugs, so it's tough. 661 00:36:57,302 --> 00:36:58,781 Okay, that's fine. 662 00:36:58,825 --> 00:37:00,870 What we're going to, for just a couple days, 663 00:37:00,914 --> 00:37:04,222 we're going to cut the dose of the CellCept in half. Okay? 664 00:37:10,967 --> 00:37:12,665 [Melena laughing] 665 00:37:12,708 --> 00:37:15,102 But you've had a headache, in particular this morning. 666 00:37:15,145 --> 00:37:16,799 -[Greg] It was splitting. -Yeah. 667 00:37:23,980 --> 00:37:26,461 Hopefully by tomorrow, it's already a better for you. 668 00:37:27,636 --> 00:37:30,117 That would be wonderful. Yeah. 669 00:37:34,904 --> 00:37:38,299 [soft music] 670 00:37:38,821 --> 00:37:40,170 [glucometer beeping] 671 00:37:41,259 --> 00:37:45,263 [soft music] 672 00:38:03,977 --> 00:38:07,763 [monitor beeping] 673 00:38:17,686 --> 00:38:22,343 [melodic music] 674 00:38:40,622 --> 00:38:42,407 [baby babbling] 675 00:38:42,711 --> 00:38:44,234 Oink. Oink. 676 00:38:45,801 --> 00:38:47,586 Ooh, those got chocolate ones too. 677 00:38:47,629 --> 00:38:49,631 Those are my favorite when I was a kid. 678 00:38:49,675 --> 00:38:51,241 Will you put one in my hand? 679 00:38:52,895 --> 00:38:54,332 Oh thank you. 680 00:38:55,594 --> 00:38:57,378 Yeah, that's my favorite. 681 00:38:58,161 --> 00:38:59,641 A lot of mail to go through. 682 00:39:00,033 --> 00:39:03,906 The disease is expensive. It's very expensive. 683 00:39:03,950 --> 00:39:05,212 Thousands of dollars 684 00:39:05,473 --> 00:39:08,128 just from the last couple years. 685 00:39:08,737 --> 00:39:10,086 This is July. 686 00:39:10,913 --> 00:39:14,308 [opening envelopes] 687 00:39:17,050 --> 00:39:19,444 I'm getting 125 bucks. 688 00:39:21,315 --> 00:39:23,143 Then there's this bill. 689 00:39:25,275 --> 00:39:27,495 What is this? Oh, that's for you. 690 00:39:28,583 --> 00:39:30,977 That doesn't even have my name on it. 691 00:39:32,195 --> 00:39:36,635 Diabetes supplies include sensors for the Dexcom, 692 00:39:36,678 --> 00:39:39,333 the CGM, the constant glucose monitoring, 693 00:39:39,377 --> 00:39:40,682 my insulin pump, 694 00:39:41,596 --> 00:39:45,687 the insulin itself, and all that stuff adds up. 695 00:39:48,473 --> 00:39:51,563 I mean, I lived for years working in restaurants, 696 00:39:52,128 --> 00:39:54,348 so, I didn't have insurance and stuff 697 00:39:54,914 --> 00:39:57,003 and I didn't have the $100 698 00:39:57,046 --> 00:39:59,092 to pay for the vials that you get. 699 00:40:00,441 --> 00:40:02,878 I'd get sick and end up in the ER 700 00:40:02,922 --> 00:40:07,883 for like eight hours getting bags and bags of fluids. 701 00:40:07,927 --> 00:40:09,624 And then they'd eventually let me leave 702 00:40:09,668 --> 00:40:11,060 with a bottle of insulin. 703 00:40:11,670 --> 00:40:15,325 which is enough to last me maybe about a month. 704 00:40:15,369 --> 00:40:16,718 Oh, a card. 705 00:40:17,502 --> 00:40:21,288 They're envelopes. But cards do come in envelopes. 706 00:40:21,331 --> 00:40:23,856 I wish they were cards. Like all birthday cards. 707 00:40:26,989 --> 00:40:28,556 Come on, pup. 708 00:40:28,600 --> 00:40:30,819 Insulin is like one of the most expensive liquids 709 00:40:30,863 --> 00:40:32,125 on earth. 710 00:40:32,473 --> 00:40:34,170 They're making a boatload of money 711 00:40:34,214 --> 00:40:36,172 from selling us all this crap. 712 00:40:36,216 --> 00:40:38,479 So I mean, why would they want to get rid of that? 713 00:40:39,654 --> 00:40:41,700 [soft music] 714 00:40:42,918 --> 00:40:44,920 I hate insulin needles. 715 00:40:44,964 --> 00:40:47,227 I hate the smell of insulin. 716 00:40:50,099 --> 00:40:52,493 I just want this disease to go away. 717 00:40:53,363 --> 00:40:57,716 [suspense music] 718 00:41:15,342 --> 00:41:17,736 This is the most important room in our house. 719 00:41:17,779 --> 00:41:21,740 This is where the world changed on October 31st, 1920. 720 00:41:21,783 --> 00:41:23,829 It was here at 2:00 AM, after a night restless sleep. 721 00:41:23,872 --> 00:41:25,744 Dr. Banting came up with this idea, 722 00:41:25,787 --> 00:41:27,833 which led to the discovery of insulin. 723 00:41:27,876 --> 00:41:32,141 Diabetes was a death sentence before the discovery of insulin. 724 00:41:33,926 --> 00:41:38,060 A hundred years ago, insulin wasn't a business. 725 00:41:38,670 --> 00:41:42,500 It was a medical breakthrough that saved millions of lives. 726 00:41:43,979 --> 00:41:46,765 When Frederick Banting accepted the Nobel Prize 727 00:41:46,808 --> 00:41:49,245 for Medicine, he famously said, 728 00:41:49,768 --> 00:41:53,989 "Insulin doesn't belong to me, it belongs to the world." 729 00:41:55,208 --> 00:41:57,427 He and his team, sold their patents 730 00:41:57,471 --> 00:42:01,649 to the University of Toronto for a dollar, each. 731 00:42:03,912 --> 00:42:09,570 Now our illness fuels a $245 billion industry 732 00:42:09,614 --> 00:42:12,181 designed to manage our disease. 733 00:42:15,620 --> 00:42:17,012 Here, I'll show you this. 734 00:42:18,274 --> 00:42:20,146 So, before they discovered insulin, 735 00:42:20,189 --> 00:42:22,452 the only way you could treat a person who has diabetes, 736 00:42:22,496 --> 00:42:25,455 like your mom, was to put him on a really horrible diet. 737 00:42:25,499 --> 00:42:30,330 And so this child is 3 years old and weighs 15 pounds. 738 00:42:31,113 --> 00:42:32,550 Do you think you weigh more than him? 739 00:42:32,593 --> 00:42:34,508 -[Jack] No. -[Grant] Oh you do. 740 00:42:34,552 --> 00:42:36,466 - [Grant] You weigh a lot more. - [Lisa] You weigh 50 pounds. 741 00:42:36,510 --> 00:42:37,903 50 pounds. 742 00:42:41,080 --> 00:42:42,734 But there's a catch 22. 743 00:42:43,343 --> 00:42:47,303 Biotech needs big pharma's profits to fund clinical trials. 744 00:42:48,087 --> 00:42:49,915 That without its support, 745 00:42:50,393 --> 00:42:52,482 the researchers wouldn't have gotten this far. 746 00:42:55,268 --> 00:42:59,098 Like most relationships, it's complicated. 747 00:43:00,273 --> 00:43:05,365 [soft music] 748 00:43:06,192 --> 00:43:09,369 It's the Flame of Hope, it was lit 30 years ago 749 00:43:09,412 --> 00:43:11,937 and it stays lit until a cure for diabetes is found. 750 00:43:12,851 --> 00:43:17,116 So, it burns for everyone around the world who has diabetes. 751 00:43:17,159 --> 00:43:18,639 Jack, you know what this means? 752 00:43:18,683 --> 00:43:20,510 If the light goes out for your mom? 753 00:43:21,163 --> 00:43:24,906 It means you don't have to get insulin no more. 754 00:43:25,646 --> 00:43:28,606 -[Lisa] No more scary nights. -[Jack] Yeah. 755 00:43:32,305 --> 00:43:36,004 [soft piano music] 756 00:43:44,317 --> 00:43:46,449 -Hi. How are you? I'm Mike. -I'm Michelle. 757 00:43:46,493 --> 00:43:48,451 Michelle, good to meet you in person. 758 00:43:48,887 --> 00:43:50,192 Sure. 759 00:43:50,236 --> 00:43:51,977 As a biotech startup company, 760 00:43:52,020 --> 00:43:54,806 there are a lot of expectations around what are we going 761 00:43:54,849 --> 00:43:57,547 to achieve and how quickly are we going to achieve it. 762 00:43:57,591 --> 00:43:59,114 Good to meet you, Mike Scott. 763 00:44:00,376 --> 00:44:02,422 There's something that's called the valley of death. 764 00:44:04,163 --> 00:44:07,079 When a startup company gets through 765 00:44:07,122 --> 00:44:08,776 an initially successful period 766 00:44:09,168 --> 00:44:10,735 and then gets to the point 767 00:44:10,778 --> 00:44:13,563 where some of the initial excitement has died, 768 00:44:13,607 --> 00:44:15,696 we're faced with trying to raise money 769 00:44:15,740 --> 00:44:19,091 without convincing clinical data yet. 770 00:44:19,569 --> 00:44:21,180 We're still making progress, 771 00:44:21,223 --> 00:44:23,704 but not to that critical juncture where you have that 772 00:44:23,748 --> 00:44:25,880 data that's going to get people over the hump of saying, 773 00:44:25,924 --> 00:44:27,360 "Yes, we're going to write a check." 774 00:44:27,403 --> 00:44:29,318 The other really key part is, 775 00:44:29,362 --> 00:44:31,538 is vascularization around the outside. 776 00:44:31,886 --> 00:44:34,454 You can see that at one end, there's a piece of tubing. 777 00:44:34,497 --> 00:44:36,848 And it's not that there isn't a lot of interest. 778 00:44:36,891 --> 00:44:39,546 It's just that the nature of investors at this stage 779 00:44:39,589 --> 00:44:42,288 is that, "Well, just show me a little nibble, 780 00:44:42,331 --> 00:44:44,638 give me a taste of the success there, 781 00:44:44,682 --> 00:44:46,858 and then I'll dump a whole ton of money in." 782 00:44:46,901 --> 00:44:49,164 And from our perspective it's, 783 00:44:49,208 --> 00:44:51,689 "Well, that's what we need the investment for, 784 00:44:52,080 --> 00:44:53,560 to collect that data. 785 00:44:53,603 --> 00:44:55,867 So, we can prove to you that this works." 786 00:44:55,910 --> 00:44:56,998 It's not going to work. 787 00:44:57,042 --> 00:44:59,174 That's the challenge right now. 788 00:44:59,609 --> 00:45:01,655 So what tugs at my heartstrings too is, I mean... 789 00:45:07,095 --> 00:45:09,097 First thing to keep in mind is, 790 00:45:09,141 --> 00:45:13,623 we're down to about $13 million and change at this point, 791 00:45:13,667 --> 00:45:15,190 including the $10 million loan. 792 00:45:15,234 --> 00:45:18,280 So, we're getting down to the nitty gritty here. 793 00:45:19,064 --> 00:45:22,894 We also have the CIRM and JDRF fundings, 794 00:45:23,242 --> 00:45:26,419 but we still need to raise some equity capital. 795 00:45:26,724 --> 00:45:31,380 Yeah, we have 180 days of cash. 796 00:45:32,425 --> 00:45:35,733 Till that, $40 million round is closed. 797 00:45:35,776 --> 00:45:39,040 We are on life support. 798 00:45:40,650 --> 00:45:42,304 In this company, 799 00:45:43,044 --> 00:45:46,526 that discontinuous development might be terminal. 800 00:45:46,569 --> 00:45:49,790 If we have to cut back on some of that core, 801 00:45:49,834 --> 00:45:54,012 the thought leaders, you lose those folks. 802 00:45:54,055 --> 00:45:56,101 There's no guarantee you're going to get them back. 803 00:45:56,144 --> 00:45:57,755 So, what you're talking about 804 00:45:57,798 --> 00:46:00,975 is not just a delay in getting back rolling again. 805 00:46:01,019 --> 00:46:04,674 You may not be able to rebuild, as effective a team. 806 00:46:07,460 --> 00:46:11,029 [soft music] 807 00:46:11,072 --> 00:46:13,683 [keyboard clattering] 808 00:46:15,685 --> 00:46:19,385 The cost of developing a drug is staggering. 809 00:46:19,646 --> 00:46:23,432 On average, $3 billion. 810 00:46:24,129 --> 00:46:27,045 That's a lot to raise from bike rides and walks. 811 00:46:29,830 --> 00:46:33,616 And while government and nonprofit funding is critical, 812 00:46:33,660 --> 00:46:36,924 it alone can't cover the cost of a clinical trial. 813 00:46:39,013 --> 00:46:41,450 So, we followed Paul, following the money. 814 00:46:43,191 --> 00:46:44,976 And that took us to Riyadh. 815 00:46:54,899 --> 00:46:56,988 It turns out that Saudi Arabia 816 00:46:57,031 --> 00:47:01,819 has one of the highest rates of type 1 diabetes in the world. 817 00:47:10,392 --> 00:47:13,482 One thing about running a biotech company is, 818 00:47:13,526 --> 00:47:15,920 you never stop raising money. 819 00:47:15,963 --> 00:47:18,226 You have to turn over a lot of rocks. 820 00:47:18,270 --> 00:47:23,057 And you don't know where the investment might come from. 821 00:47:23,101 --> 00:47:26,234 This really represents potentially a functional cure. 822 00:47:26,278 --> 00:47:28,323 If this works as well in humans, 823 00:47:28,367 --> 00:47:30,804 as it has in the animal models we study, 824 00:47:30,848 --> 00:47:32,893 it would essentially take it to a disease 825 00:47:32,937 --> 00:47:36,375 where patients no longer have to think about it any further. 826 00:47:37,245 --> 00:47:39,160 Does the American public understand 827 00:47:39,204 --> 00:47:41,336 the cost of developing a cure? 828 00:47:42,337 --> 00:47:44,426 I don't think they really have much of a clue 829 00:47:44,470 --> 00:47:48,126 as to what goes into getting that funding 830 00:47:48,169 --> 00:47:50,084 and how much you have to raise. 831 00:47:50,128 --> 00:47:52,870 -Hi, Paul Laikind. -Hi, nice to meet you. 832 00:47:56,525 --> 00:47:59,093 We've raised about $70 million 833 00:47:59,137 --> 00:48:00,486 in venture financing. 834 00:48:00,529 --> 00:48:03,271 In total, it's about $150 million 835 00:48:03,315 --> 00:48:05,143 that's been invested in a company to date 836 00:48:05,186 --> 00:48:06,971 to get us to where we are. 837 00:48:09,756 --> 00:48:13,238 [chuckling] That's the billion dollar question. 838 00:48:13,281 --> 00:48:14,761 [both laughing] 839 00:48:15,588 --> 00:48:17,590 What happens if you don't raise the money? 840 00:48:18,373 --> 00:48:19,897 Shut the doors. 841 00:48:26,425 --> 00:48:30,908 [suspense music] 842 00:48:35,042 --> 00:48:38,524 [subway train revving] 843 00:48:40,004 --> 00:48:43,137 [indistinct chatter] 844 00:48:49,274 --> 00:48:52,625 We're going to meet with a large pharmaceutical firm. 845 00:48:52,668 --> 00:48:55,280 It's been doing due diligence on ViaCyte. 846 00:48:57,151 --> 00:48:58,718 So, what we're looking for 847 00:48:58,761 --> 00:49:00,285 is that they would be able to take 848 00:49:00,328 --> 00:49:01,764 a position in the company, 849 00:49:01,808 --> 00:49:03,375 invest in the company to the tune 850 00:49:03,418 --> 00:49:05,159 of about $15 million or so. 851 00:49:08,423 --> 00:49:13,341 All right, so tomorrow we start at 9:00 AM. 852 00:49:15,039 --> 00:49:16,736 ViaCyte is a small fish. 853 00:49:17,258 --> 00:49:18,956 We're good at inventing. 854 00:49:18,999 --> 00:49:20,435 We're good at innovating, 855 00:49:20,479 --> 00:49:22,263 but we don't have deep pockets. 856 00:49:22,785 --> 00:49:25,788 And that's where big pharma can play a critical role 857 00:49:25,832 --> 00:49:27,747 in taking this new technology 858 00:49:27,790 --> 00:49:30,184 to the many, many patients who need it. 859 00:49:33,535 --> 00:49:35,973 -Exactly. -[all laughing] 860 00:49:38,888 --> 00:49:41,717 It's not that big pharma companies don't take risks, 861 00:49:41,979 --> 00:49:43,632 they take a wait and see attitude 862 00:49:44,155 --> 00:49:46,635 until it's proven that the benefit outweighs the risk. 863 00:49:53,468 --> 00:49:56,994 This is a byproduct of our profit driven society, 864 00:49:57,037 --> 00:49:58,647 where we have to answer to shareholders. 865 00:50:02,434 --> 00:50:06,873 That's the reality of national and international business. 866 00:50:06,916 --> 00:50:09,180 [soft music] 867 00:50:16,187 --> 00:50:19,538 [indistinct chatter] 868 00:50:20,626 --> 00:50:24,760 Ladies and gentlemen, welcome to the Shinkansen. 869 00:50:25,283 --> 00:50:28,199 This is the Hikari Super Express. 870 00:50:30,592 --> 00:50:35,771 We will be stopping at [speaking foreign language] 871 00:50:36,468 --> 00:50:41,255 [blissful piano music] 872 00:50:43,518 --> 00:50:45,477 Start running and then jump on it. 873 00:50:46,043 --> 00:50:49,089 I'm serious. Run, run, run. 874 00:50:55,095 --> 00:50:56,879 What you go over there for? 875 00:50:58,055 --> 00:50:59,273 [Maren laughing] 876 00:51:01,145 --> 00:51:04,322 [squealing] 877 00:51:06,715 --> 00:51:09,718 Someone will be taken out before the end of this. 878 00:51:10,719 --> 00:51:12,373 I just hope it's not me. 879 00:51:12,765 --> 00:51:14,114 [lighthearted music] 880 00:51:15,724 --> 00:51:18,118 [Maren squealing] 881 00:51:21,904 --> 00:51:24,690 It's fun. It's exciting. 882 00:51:24,733 --> 00:51:28,085 It's scary but I can't explain what is happening. 883 00:51:29,347 --> 00:51:31,218 I've had two explants. 884 00:51:31,262 --> 00:51:33,960 I had two taken out of my side and one taken out of my arm. 885 00:51:34,265 --> 00:51:36,310 One in October and one in December. 886 00:51:38,399 --> 00:51:41,533 It's exhausting. I'm tired. 887 00:51:42,186 --> 00:51:43,622 It's a lot physically. 888 00:51:43,665 --> 00:51:44,840 It's a lot mentally, it's a lot emotionally. 889 00:51:46,146 --> 00:51:48,888 It has been more than I ever expected. 890 00:51:48,931 --> 00:51:52,674 Okay. So now Amber, don't squish them but shake it. 891 00:51:53,240 --> 00:51:54,633 Shake it. 892 00:51:59,812 --> 00:52:03,294 That's the last 24 hours. 893 00:52:04,817 --> 00:52:06,819 My insulin dose is about half, 894 00:52:06,862 --> 00:52:09,038 but 50% overall. 895 00:52:10,605 --> 00:52:13,173 I feel good, down about 20 pounds 896 00:52:13,217 --> 00:52:14,740 without even trying. 897 00:52:15,654 --> 00:52:19,397 I haven't had any extreme lows. Have I Case? 898 00:52:19,832 --> 00:52:22,182 No extreme lows, but you've had lows. 899 00:52:22,226 --> 00:52:25,403 Lows, but not extreme lows. No extreme highs. 900 00:52:25,881 --> 00:52:27,927 So, I think it's definitely narrowed the gap. 901 00:52:28,536 --> 00:52:30,886 Sounds like the cells are working. 902 00:52:32,323 --> 00:52:33,889 Something's working. 903 00:52:34,194 --> 00:52:36,022 I don't know what's working, something's working. 904 00:52:37,937 --> 00:52:39,765 What does Dr. Bellin say? 905 00:52:39,808 --> 00:52:41,810 She said something 906 00:52:41,854 --> 00:52:43,812 that have pointed me in the direction that, 907 00:52:44,161 --> 00:52:45,597 "Oh, they know something, 908 00:52:45,640 --> 00:52:47,338 but they're not filling me in on everything, 909 00:52:47,381 --> 00:52:49,209 'cause I think they're cautiously optimistic as well." 910 00:52:50,776 --> 00:52:53,692 I never had super high expectations to begin with, 911 00:52:53,735 --> 00:52:55,302 but this is better than I ever expected. 912 00:52:55,346 --> 00:52:56,651 Even where I'm at right now. 913 00:52:56,695 --> 00:52:59,567 So, would you agree with that Case? 914 00:52:59,611 --> 00:53:01,221 - [Case] I wasn't listening. -[Maren] Okay. 915 00:53:02,483 --> 00:53:05,921 [soft piano music] 916 00:53:05,965 --> 00:53:08,968 [phone ringing] 917 00:53:09,273 --> 00:53:10,926 Hi Howard. 918 00:53:41,218 --> 00:53:43,698 I don't believe it, necessarily. 919 00:53:46,266 --> 00:53:47,789 Why not? You've been telling us 920 00:53:47,833 --> 00:53:49,487 that the C-peptide is the gold standard test. 921 00:53:49,530 --> 00:53:51,010 It's the gold standard. 922 00:53:51,053 --> 00:53:54,405 I'm not convinced given that level of C-peptide, 923 00:53:54,448 --> 00:53:56,755 given that it's a solitary measurement. 924 00:53:56,798 --> 00:53:59,584 And given that it's a single patient. 925 00:53:59,627 --> 00:54:00,759 I don't get it. 926 00:54:00,802 --> 00:54:03,631 You guys would get desensitized 927 00:54:03,675 --> 00:54:05,633 if you were following each and every patient 928 00:54:05,677 --> 00:54:07,548 of the 11 we're doing right now, 929 00:54:07,592 --> 00:54:09,898 but you're focusing in on two patients, 930 00:54:09,942 --> 00:54:12,074 the two patients at the Minnesota site. 931 00:54:13,728 --> 00:54:15,339 Everybody's hopeful. 932 00:54:15,382 --> 00:54:17,254 -[Howard] Yeah, well. -[Lisa] Even the PI. 933 00:54:17,297 --> 00:54:18,559 Yeah, I know. 934 00:54:18,603 --> 00:54:21,214 That's why they pay me to be skeptical. 935 00:54:24,696 --> 00:54:29,222 [engine roaring] 936 00:54:30,963 --> 00:54:32,486 Deep breath. 937 00:54:34,575 --> 00:54:37,274 Good. Did you check your wristband to make sure 938 00:54:37,317 --> 00:54:38,666 that everything's right on there? 939 00:54:38,710 --> 00:54:40,189 -Sure. -What's your birthday? 940 00:54:40,233 --> 00:54:42,366 -Today. -It's your birthday today? 941 00:54:42,409 --> 00:54:45,325 -Yes. Happy birthday. -Yeah. 942 00:54:46,979 --> 00:54:51,984 [soft piano music] 943 00:55:07,086 --> 00:55:10,611 [trolley rolling] 944 00:55:12,047 --> 00:55:15,442 [suspense music] 945 00:55:16,008 --> 00:55:19,185 [monitor beeping] 946 00:55:27,106 --> 00:55:33,460 [suspense music] 947 00:55:50,085 --> 00:55:52,784 [suspenseful music] 948 00:56:16,721 --> 00:56:20,899 [suspenseful music] 949 00:56:34,216 --> 00:56:36,828 I would say this cell survival is moderate. 950 00:56:37,785 --> 00:56:40,266 It just looks like, to me, they might be fewer 951 00:56:40,309 --> 00:56:42,486 than we would hope for at... 952 00:56:42,921 --> 00:56:44,575 12 weeks. 953 00:56:44,618 --> 00:56:46,838 ...Which is a pretty definitive time point. 954 00:56:47,447 --> 00:56:49,667 It can keep going up after that, 955 00:56:49,928 --> 00:56:51,669 but I wish it were more right now. 956 00:56:51,712 --> 00:56:54,193 Or you would expect it to continue 957 00:56:54,236 --> 00:56:55,890 to increase after 12 weeks. 958 00:56:55,934 --> 00:56:57,152 Yes. 959 00:56:58,458 --> 00:57:02,201 [soft piano music] 960 00:57:07,032 --> 00:57:09,338 [indistinct chatter] 961 00:57:13,038 --> 00:57:15,910 It's been 12 weeks since Maren got her implant 962 00:57:15,954 --> 00:57:19,827 and still no C-peptide levels have shown up in her blood. 963 00:57:22,177 --> 00:57:24,353 [elevator alarm ringing] 964 00:57:24,397 --> 00:57:27,356 The researchers think her cells should have matured by now. 965 00:57:28,314 --> 00:57:30,011 They should be producing insulin. 966 00:57:36,278 --> 00:57:37,976 Do you think it's fair to say 967 00:57:38,019 --> 00:57:40,979 that the patient shouldn't give up hope just yet, 968 00:57:41,545 --> 00:57:43,329 because as you always tell me, Howard. 969 00:57:43,372 --> 00:57:44,591 Rats are not humans 970 00:57:44,635 --> 00:57:46,767 and this is an experimental study. 971 00:57:47,420 --> 00:57:48,943 Sure. Absolutely. 972 00:57:48,987 --> 00:57:52,599 I mean, you have to consider the outcome. 973 00:57:52,643 --> 00:57:55,907 In rodent, the earliest that we would anticipate 974 00:57:55,950 --> 00:57:59,563 seeing C-peptide is on the order of two to three months, 975 00:58:00,128 --> 00:58:03,784 again though, that is depending upon the assumption 976 00:58:03,828 --> 00:58:07,788 that the time course in man, is the same as that in rodent. 977 00:58:07,832 --> 00:58:09,747 And we do not know that for sure. 978 00:58:09,790 --> 00:58:12,053 So, we're still in the game with these two patients? 979 00:58:12,358 --> 00:58:14,229 We're still in the game with these two patients 980 00:58:14,273 --> 00:58:15,796 and we haven't ruled them out. 981 00:58:16,449 --> 00:58:17,798 Just want to know, 982 00:58:17,842 --> 00:58:19,278 we've been working together for a long time 983 00:58:19,321 --> 00:58:20,975 and want to know like, 984 00:58:21,019 --> 00:58:23,935 "Hey, I should still have hope, me. 985 00:58:23,978 --> 00:58:28,026 Not the filmmaker, but me Lisa, the patient." 986 00:58:28,505 --> 00:58:30,463 I mean, everything is getting better. 987 00:58:30,724 --> 00:58:32,073 You just have to be patient. 988 00:58:32,683 --> 00:58:34,859 All right, Howard. Thanks for your time. 989 00:58:35,599 --> 00:58:36,904 Okay. Bye-bye. 990 00:58:43,868 --> 00:58:46,435 Hi, I'm just going to complain the whole time. 991 00:58:46,479 --> 00:58:48,568 I'm a mess of a wreck. 992 00:58:50,962 --> 00:58:53,268 I don't know if I can keep doing this anymore. 993 00:58:56,097 --> 00:59:00,058 I might have to go back in today again, 994 00:59:00,101 --> 00:59:02,147 which would be surgery number five 995 00:59:02,190 --> 00:59:08,545 in four months, and so tired. 996 00:59:09,850 --> 00:59:11,635 Tired doing this and 997 00:59:12,636 --> 00:59:15,769 so much physically and emotionally on me. 998 00:59:19,294 --> 00:59:22,341 All this in hopes of the cure. 999 00:59:25,344 --> 00:59:30,001 [car engine revving] 1000 00:59:37,269 --> 00:59:40,838 I can't compare this experience to anything in my life, ever. 1001 00:59:41,186 --> 00:59:44,537 It has been an emotional rollercoaster, 1002 00:59:44,581 --> 00:59:45,930 is the only way to explain it. 1003 00:59:47,018 --> 00:59:48,628 I would give anything. 1004 00:59:48,672 --> 00:59:51,936 If I could sit down with the people doing the study 1005 00:59:51,979 --> 00:59:53,677 out in San Diego and say, 1006 00:59:53,720 --> 00:59:55,330 "This is what it's like on our end. 1007 00:59:55,374 --> 00:59:56,767 You can go ahead and see my labs. 1008 00:59:56,810 --> 00:59:57,855 You can go ahead and see the blood work. 1009 00:59:58,682 --> 01:00:00,597 But, talk to Greg and me. 1010 01:00:00,640 --> 01:00:02,381 Talk to us about how we're doing." 1011 01:00:02,424 --> 01:00:03,774 Nice and close. 1012 01:00:04,165 --> 01:00:06,167 But I'm going to have to stick it out 1013 01:00:06,211 --> 01:00:09,518 until someone tells me to stop. 1014 01:00:11,346 --> 01:00:12,739 I don't know what else to do. 1015 01:00:12,783 --> 01:00:14,785 I mean, I'm knee deep in horse shit. 1016 01:00:14,828 --> 01:00:16,351 So, I don't know 1017 01:00:16,395 --> 01:00:17,831 what I'm supposed to do. 1018 01:00:17,875 --> 01:00:19,616 I mean, I've already got eight incisions 1019 01:00:19,659 --> 01:00:22,270 all over my body and been a lab rat. 1020 01:00:22,314 --> 01:00:24,185 I'm this far into it. I might as well keep going. 1021 01:00:24,708 --> 01:00:28,320 [monitor beeping] 1022 01:00:31,279 --> 01:00:34,892 [soft piano music] 1023 01:00:39,940 --> 01:00:42,900 Me and the other patients are experiencing 1024 01:00:42,943 --> 01:00:44,945 better glucose numbers. 1025 01:00:45,511 --> 01:00:47,469 And I think that could be attributed 1026 01:00:47,513 --> 01:00:50,298 to a placebo effect because we're under a microscope. 1027 01:00:52,518 --> 01:00:54,259 Humans are self-conscious. 1028 01:00:55,913 --> 01:00:58,089 And they wanna leave a good impression 1029 01:01:00,526 --> 01:01:03,311 So, looking at this at the broad overview, 1030 01:01:03,355 --> 01:01:05,966 I'd say you're doing reasonably well. 1031 01:01:06,010 --> 01:01:07,707 I mean, you're in target 70% of the time. 1032 01:01:07,751 --> 01:01:09,491 Yeah. 1033 01:01:09,535 --> 01:01:10,797 You obviously have some highs, but we expect that. 1034 01:01:10,841 --> 01:01:12,407 You have some lows, but they seem like 1035 01:01:12,451 --> 01:01:14,627 they're pretty brief in nature. 1036 01:01:14,671 --> 01:01:17,674 You have a little more highs maybe after lunchtime, 1037 01:01:17,717 --> 01:01:19,632 but nothing that I'm concerned about for you. 1038 01:01:20,807 --> 01:01:22,243 Do you think it's working? 1039 01:01:22,766 --> 01:01:25,943 I do. I think it's doing something 1040 01:01:25,986 --> 01:01:30,817 because my disease seems easier to manage, 1041 01:01:30,861 --> 01:01:33,211 but it could just be me. 1042 01:01:33,254 --> 01:01:35,648 Oh, I like the socks today. 1043 01:01:35,692 --> 01:01:36,954 Yeah. Striped. 1044 01:01:38,956 --> 01:01:41,393 [door opening] 1045 01:01:58,584 --> 01:02:01,456 Used to play a lot of craps on the streets. 1046 01:02:01,500 --> 01:02:04,938 I should probably paint some dots on this thing. 1047 01:02:04,982 --> 01:02:06,070 Make him feel at home. 1048 01:02:10,074 --> 01:02:13,077 -[Lisa] What is that, Greg? - [Greg] This is my father. 1049 01:02:15,383 --> 01:02:19,605 He passed away about a year ago from complications 1050 01:02:19,648 --> 01:02:22,869 of Pneumonia and diabetes. 1051 01:02:24,001 --> 01:02:26,307 -Is there an urn in it? -This is an urn. 1052 01:02:26,351 --> 01:02:27,613 -Oh, that's the urn. -Yeah. 1053 01:02:28,440 --> 01:02:31,051 For a Mexican family, this is it, man. 1054 01:02:31,312 --> 01:02:32,618 This is what we got. 1055 01:02:32,879 --> 01:02:34,054 Yeah, 1056 01:02:35,839 --> 01:02:37,101 this is him. 1057 01:02:39,190 --> 01:02:41,366 He was in a nursing home 1058 01:02:41,409 --> 01:02:43,760 due to a hypoglycemic episode 1059 01:02:43,803 --> 01:02:47,154 that left him mentally handicapped. 1060 01:02:47,764 --> 01:02:50,418 He couldn't live on his own. He couldn't function. 1061 01:02:51,071 --> 01:02:52,769 He had to relearn how to talk 1062 01:02:52,812 --> 01:02:55,423 and he... but he relearned, barely. 1063 01:02:56,511 --> 01:03:00,907 So yeah, this is: Gregory Romero Senior. 1064 01:03:11,091 --> 01:03:13,615 Gracious God, we thank you for Maren. 1065 01:03:13,659 --> 01:03:15,574 And for the love that she has, 1066 01:03:15,617 --> 01:03:17,881 that has been poured out into so many lives. 1067 01:03:17,924 --> 01:03:21,406 And especially of all her kids, who are gathered around her now. 1068 01:03:21,841 --> 01:03:23,625 Heavenly father, we pray for Maren 1069 01:03:23,669 --> 01:03:26,498 and for the doctors who will be looking after her, 1070 01:03:26,541 --> 01:03:30,067 we ask that your presence will be with Maren 1071 01:03:30,110 --> 01:03:32,069 and be with the rest of her family. 1072 01:03:32,112 --> 01:03:33,810 Lord, we lift her up to you 1073 01:03:33,853 --> 01:03:37,857 and know that she is in your careful and loving arms. 1074 01:03:37,901 --> 01:03:39,467 In Jesus' name, we pray. 1075 01:03:39,511 --> 01:03:41,034 -[Pastor] Amen. -[All] Amen. 1076 01:03:41,730 --> 01:03:43,994 [soft music] 1077 01:03:44,037 --> 01:03:45,822 Katelyn, can stand up. 1078 01:03:46,866 --> 01:03:51,392 [indistinct chatter] 1079 01:03:59,009 --> 01:04:00,967 So, you're getting some results today? 1080 01:04:01,750 --> 01:04:03,274 Hopefully I find something out, 1081 01:04:03,317 --> 01:04:04,797 either yes or no. 1082 01:04:05,493 --> 01:04:08,105 Are the cell's dead or are they alive? 1083 01:04:09,933 --> 01:04:14,198 [soft music] 1084 01:04:17,984 --> 01:04:20,247 Okay, so they did the explants, right? 1085 01:04:20,291 --> 01:04:22,162 Yep. So this is the January one. 1086 01:04:22,206 --> 01:04:24,599 -This is the most recent one. -Okay. A couple weeks ago. 1087 01:04:24,643 --> 01:04:27,124 Remember they were looking at the T cells before 1088 01:04:27,167 --> 01:04:29,082 that cause rejection. 1089 01:04:29,126 --> 01:04:30,692 So, they still see those cells. 1090 01:04:30,736 --> 01:04:33,652 Around the implant and inside of it. 1091 01:04:33,695 --> 01:04:38,091 They see very, very few from what they told me, 1092 01:04:38,135 --> 01:04:39,876 actual donor cells anymore. 1093 01:04:39,919 --> 01:04:41,573 Interesting, okay. Yep. 1094 01:04:42,574 --> 01:04:44,663 They don't think that there's any chance 1095 01:04:44,706 --> 01:04:46,926 that the remaining ones are going to make insulin. 1096 01:04:47,622 --> 01:04:50,016 Is this happening with everyone? Do you know? 1097 01:04:50,321 --> 01:04:52,758 So, you are the only person 1098 01:04:52,801 --> 01:04:57,023 in the study so far that has had this type of rejection. 1099 01:04:57,067 --> 01:04:58,677 Interesting. 1100 01:04:58,720 --> 01:05:01,506 So from our standpoint, if they're not going to work, 1101 01:05:01,854 --> 01:05:03,638 then we're putting medicine that you don't need, 1102 01:05:03,682 --> 01:05:05,727 leaving them in when you don't need it. 1103 01:05:10,341 --> 01:05:12,778 [soft music] 1104 01:05:28,359 --> 01:05:30,665 Truly, truly I'm relieved. 1105 01:05:31,101 --> 01:05:34,017 I feel like I can breathe. 1106 01:05:36,019 --> 01:05:37,803 It's been a long five months. 1107 01:05:37,846 --> 01:05:39,892 It's been a really long five months. 1108 01:05:40,371 --> 01:05:42,503 Six months almost since the start of it. 1109 01:05:44,114 --> 01:05:46,507 I feel like I can maybe go back to normal for a bit, 1110 01:05:49,597 --> 01:05:52,339 My normal, whatever my normal is. 1111 01:05:58,780 --> 01:06:01,218 [soft music] 1112 01:06:25,459 --> 01:06:28,636 Do you feel guilty that the cure is always 5 years away? 1113 01:06:28,680 --> 01:06:31,726 I don't feel guilty. I feel hopeful. 1114 01:06:32,684 --> 01:06:35,382 I feel really hopeful. I'm not kidding. 1115 01:06:35,426 --> 01:06:37,384 -You do? -Yes. 1116 01:06:37,428 --> 01:06:38,864 -Really, for real? -That's so nice of you. 1117 01:06:38,907 --> 01:06:41,998 I'm working here. I can see what's going on. 1118 01:06:45,262 --> 01:06:46,611 It's going to be good for you. 1119 01:06:46,654 --> 01:06:48,787 I know it's been really hard as heck. 1120 01:06:54,662 --> 01:06:56,273 Thanks. 1121 01:06:56,316 --> 01:06:57,709 I'm not kidding. 1122 01:06:58,231 --> 01:06:59,580 It's true. 1123 01:07:00,103 --> 01:07:03,758 I mean, there's nobody, no person with a Dexcom 1124 01:07:03,802 --> 01:07:07,849 or a pump or anything works as well as the cells. 1125 01:07:09,112 --> 01:07:12,289 The cells have evolved over millions of years. 1126 01:07:12,593 --> 01:07:15,553 They're the best glucose sensors, the best insulin 1127 01:07:16,293 --> 01:07:18,947 pumps in the world. 1128 01:07:18,991 --> 01:07:20,340 That's what biology's all about. 1129 01:07:20,384 --> 01:07:23,996 And that's why we're doing it this way. 1130 01:07:24,040 --> 01:07:26,259 It takes a ton of work and a ton of money, 1131 01:07:26,303 --> 01:07:27,956 but it's worth it. 1132 01:07:31,786 --> 01:07:36,443 [suspense music] 1133 01:07:38,141 --> 01:07:39,490 That's good. 1134 01:07:39,533 --> 01:07:41,970 We want them to get blood vessels. 1135 01:07:42,014 --> 01:07:43,276 Oh, that's great. 1136 01:07:45,148 --> 01:07:48,368 The loading port, right? 1137 01:07:48,412 --> 01:07:51,371 -[Nurse] Do you see it, Greg? -[Greg] It's the top one. 1138 01:07:51,632 --> 01:07:54,331 And for the other one, there it is. 1139 01:07:54,374 --> 01:07:56,289 And then the port, port, port. 1140 01:07:57,247 --> 01:07:59,684 So if I come up this way. 1141 01:08:06,299 --> 01:08:07,996 [elevator dings] 1142 01:08:09,172 --> 01:08:12,740 [soft music] 1143 01:08:17,093 --> 01:08:18,659 I used to have great vision. 1144 01:08:20,139 --> 01:08:21,967 I remember as a child, 1145 01:08:22,010 --> 01:08:24,796 my dad being diabetic would ask me to look down the street 1146 01:08:24,839 --> 01:08:26,754 and see what bus is coming 1147 01:08:27,190 --> 01:08:28,452 and I'd have to tell him. 1148 01:08:29,061 --> 01:08:31,281 And I'm like, "How do you not see that?" 1149 01:08:36,024 --> 01:08:37,591 Now I understand. 1150 01:08:40,638 --> 01:08:42,161 Mr. Romero. 1151 01:08:42,205 --> 01:08:43,554 -[Greg] Hi. -[Doctor] How are you doing? 1152 01:08:43,597 --> 01:08:45,556 -Good, how are you? -Good, good. 1153 01:08:45,599 --> 01:08:47,340 Your left eye vision seems a lot more blurry 1154 01:08:47,384 --> 01:08:49,037 than it was last time I saw you. 1155 01:08:49,081 --> 01:08:50,300 It is a little bit. 1156 01:08:50,343 --> 01:08:52,084 Let me take a look real quick. 1157 01:08:52,519 --> 01:08:54,478 I looked at your pictures 1158 01:08:54,521 --> 01:08:57,829 and I have a suspicion as to what's going on. 1159 01:08:59,831 --> 01:09:01,224 Look up. 1160 01:09:01,963 --> 01:09:03,443 Up and left. 1161 01:09:05,532 --> 01:09:07,143 and down, 1162 01:09:07,882 --> 01:09:09,449 down and right. 1163 01:09:11,669 --> 01:09:12,670 And right. 1164 01:09:17,414 --> 01:09:18,806 And left. 1165 01:09:26,814 --> 01:09:30,992 So, it seems that you've had some bleeding 1166 01:09:31,036 --> 01:09:34,257 inside your left eye from the diabetes. 1167 01:09:34,300 --> 01:09:39,697 Yeah, I see a floater or it looks like a drop of blood. 1168 01:09:39,740 --> 01:09:41,438 Yeah. 1169 01:09:41,481 --> 01:09:43,353 So, that's probably at the bottom of my eye somewhere. 1170 01:09:43,396 --> 01:09:44,919 Yeah, there's quite a bit of blood in there 1171 01:09:44,963 --> 01:09:46,834 that is blocking your vision. 1172 01:09:46,878 --> 01:09:49,141 And it's definitely worse than it was last time we saw you. 1173 01:09:49,185 --> 01:09:51,317 If it fails to clear, we might have to do surgery, 1174 01:09:51,361 --> 01:09:53,189 -but I'm hoping to avoid that. -Okay. 1175 01:09:53,711 --> 01:09:55,800 -Thank you very much. -Oh, sure. 1176 01:09:56,453 --> 01:09:59,456 Yeah, whatever. 1177 01:10:01,371 --> 01:10:03,721 It's all part of the experience, I guess. 1178 01:10:09,030 --> 01:10:11,294 I can't fucking see. 1179 01:10:17,561 --> 01:10:19,650 [dog barking] 1180 01:10:22,479 --> 01:10:25,264 The study is the positive thing for me right now. 1181 01:10:25,308 --> 01:10:26,831 We're just waiting. 1182 01:10:26,874 --> 01:10:28,920 We're all waiting to see if these things work. 1183 01:10:28,963 --> 01:10:30,269 If they don't, 1184 01:10:31,009 --> 01:10:33,098 we'll cross that bridge when we get to it. 1185 01:10:35,405 --> 01:10:40,018 I have neuropathy, retinopathy 1186 01:10:41,846 --> 01:10:43,500 and other 1187 01:10:45,284 --> 01:10:47,852 complications due to the high blood sugars 1188 01:10:47,895 --> 01:10:49,027 throughout the years. 1189 01:10:49,070 --> 01:10:52,117 A lot of nerve damage I have. 1190 01:10:54,641 --> 01:10:56,252 I'm sorry. 1191 01:10:59,167 --> 01:11:01,300 I'm not going to say what I was just going to say. 1192 01:11:01,344 --> 01:11:02,736 But yeah. 1193 01:11:04,085 --> 01:11:06,262 You suffer from the disease as well. 1194 01:11:06,305 --> 01:11:08,307 So, I'm sorry too. 1195 01:11:10,614 --> 01:11:12,790 It's something that we're all going to have 1196 01:11:12,833 --> 01:11:15,619 to encounter and deal with, every one of us. 1197 01:11:21,886 --> 01:11:23,279 Sorry. 1198 01:11:27,848 --> 01:11:29,676 But if these cells work, 1199 01:11:38,511 --> 01:11:40,121 I'll cry for a week, 1200 01:11:41,862 --> 01:11:43,603 like, out loud 1201 01:11:45,910 --> 01:11:48,695 and I'm not the type of person to do that very much. 1202 01:11:56,964 --> 01:11:58,183 I'm tired. 1203 01:12:34,915 --> 01:12:37,483 [suspense music] 1204 01:12:37,918 --> 01:12:40,704 You had the ViaCyte? 1205 01:12:40,747 --> 01:12:42,401 -[Maren] Yeah. -[Nurse] Are they all gone now? 1206 01:12:42,445 --> 01:12:43,837 -They're gone. -Okay. 1207 01:12:43,881 --> 01:12:45,535 I assume they're gone. 1208 01:12:45,926 --> 01:12:47,319 I got a phone call 1209 01:12:47,363 --> 01:12:50,017 and there's a pancreas available. 1210 01:12:50,453 --> 01:12:53,499 I thought about it for years, for years. 1211 01:12:53,543 --> 01:12:56,633 And the trial gave me 1212 01:12:57,024 --> 01:12:58,896 the opportunity to try the medicine 1213 01:12:58,939 --> 01:13:00,201 and see how I handled it. 1214 01:13:00,245 --> 01:13:02,769 And I handled it just fine. 1215 01:13:02,813 --> 01:13:04,641 Recent changes in your vision or your hearing? 1216 01:13:04,684 --> 01:13:05,946 No. 1217 01:13:05,990 --> 01:13:07,426 So, it opened the door for me 1218 01:13:07,992 --> 01:13:10,821 to think more about doing this transplant. 1219 01:13:10,864 --> 01:13:12,039 -Sore throat? -No. 1220 01:13:12,083 --> 01:13:13,954 I would do the trial over again. 1221 01:13:13,998 --> 01:13:15,956 I would do everything all over again. 1222 01:13:16,000 --> 01:13:17,393 'Cause, it got me to this point. 1223 01:13:18,132 --> 01:13:20,091 I have zero regrets. 1224 01:13:21,658 --> 01:13:22,920 Zero. 1225 01:13:29,317 --> 01:13:31,407 -[Greg] Hi. -[Maren] Hi, come here. 1226 01:13:34,410 --> 01:13:36,629 -How are you? -Good, how are you? 1227 01:13:36,673 --> 01:13:37,891 Okay. 1228 01:13:45,943 --> 01:13:48,032 I'm going to sneak a hug in there. 1229 01:13:48,075 --> 01:13:49,990 See you. Wish me luck. 1230 01:13:50,034 --> 01:13:51,557 I'm going to see you next time. 1231 01:13:52,515 --> 01:13:53,907 We'll go out for cheesecake. 1232 01:13:54,691 --> 01:13:57,737 -[Maren] Cheesecake Factory -[all laughing] 1233 01:13:58,477 --> 01:14:01,480 -with sugar. -[all laughing] 1234 01:14:01,524 --> 01:14:03,700 Okay. Take care. 1235 01:14:03,743 --> 01:14:06,137 Come visit me. Okay? 1236 01:14:10,054 --> 01:14:11,708 All right. We'll see you, Greg. 1237 01:14:20,673 --> 01:14:22,153 One, two, three. 1238 01:14:26,549 --> 01:14:29,377 A friend of mine that had a pancreas transplant 1239 01:14:29,421 --> 01:14:31,815 a year and a half ago, text me this afternoon. 1240 01:14:31,858 --> 01:14:35,253 She goes, "You'll wake up tomorrow with a new life." 1241 01:14:36,950 --> 01:14:38,778 So, it was pretty cool. 1242 01:14:39,953 --> 01:14:42,782 So, fingers crossed. 1243 01:14:50,355 --> 01:14:55,142 [car honking] 1244 01:14:57,536 --> 01:15:00,757 I've been going with Paul to meetings 1245 01:15:00,800 --> 01:15:05,196 with potential investors for the last two years. 1246 01:15:05,588 --> 01:15:07,546 Every time you're like, "Oh, this is it." 1247 01:15:07,590 --> 01:15:10,723 These guys get it. They're excited about it. 1248 01:15:10,767 --> 01:15:12,116 And then 1249 01:15:13,291 --> 01:15:16,424 they just don't call you back. 1250 01:15:16,468 --> 01:15:19,819 Don't reply the email. Or 1251 01:15:20,559 --> 01:15:22,996 It just falls apart one way or the other. 1252 01:15:23,040 --> 01:15:27,087 So, that's been really hard. 1253 01:15:28,088 --> 01:15:30,526 [Virtual Assistant] The pouch is designed to fully contain 1254 01:15:30,569 --> 01:15:32,092 the implant itself, 1255 01:15:32,136 --> 01:15:34,225 but still allow vital nutrients and proteins 1256 01:15:34,268 --> 01:15:36,575 such as oxygen, glucose, insulin, 1257 01:15:36,619 --> 01:15:39,578 and other hormones to travel between the cells. 1258 01:15:39,622 --> 01:15:41,362 Well, it's nice. It's a good description of the product. 1259 01:15:41,406 --> 01:15:42,755 Well, it's nice. Good to see you. 1260 01:15:42,799 --> 01:15:44,627 All right. 1261 01:15:45,062 --> 01:15:47,064 [indistinct chatter] 1262 01:15:50,850 --> 01:15:54,201 I'm really pleased to announce that as of this morning, 1263 01:15:54,245 --> 01:15:55,768 the checks rolled in 1264 01:15:55,812 --> 01:16:00,077 and we completed an $80 million financing for ViaCyte. 1265 01:16:00,556 --> 01:16:03,950 [crowd applauding] 1266 01:16:04,647 --> 01:16:07,911 That's $105 million over the last three months. 1267 01:16:08,215 --> 01:16:10,130 It's really exciting, 1268 01:16:10,174 --> 01:16:12,219 but boy, we're going to be under pressure to perform. 1269 01:16:12,263 --> 01:16:15,919 I believe that everybody in here will redouble their efforts 1270 01:16:15,962 --> 01:16:18,704 to really show this new group of investors 1271 01:16:18,748 --> 01:16:20,314 that they made a great decision. 1272 01:16:21,577 --> 01:16:24,492 [crowd applauds] 1273 01:16:24,928 --> 01:16:28,758 All right, let's do a toast to the success of this team, 1274 01:16:28,801 --> 01:16:32,936 the success of this program and to curing type 1 diabetes. 1275 01:16:33,197 --> 01:16:36,069 [crowd applauding] 1276 01:16:37,680 --> 01:16:40,944 I feel like Paul has mastered the game of selling risk. 1277 01:16:43,424 --> 01:16:47,603 He convinces venture capitalists to embrace the long game, 1278 01:16:47,646 --> 01:16:50,997 that science takes time and progress is incremental. 1279 01:16:51,041 --> 01:16:53,783 You got to be optimistic and stress resistant. 1280 01:16:53,826 --> 01:16:55,436 [Paul laughing] 1281 01:16:55,480 --> 01:16:56,916 Two criteria. 1282 01:16:56,960 --> 01:16:59,049 If it doesn't work in patient two, 1283 01:16:59,092 --> 01:17:01,834 it's going to work in 22. 1284 01:17:04,445 --> 01:17:07,492 But what if Paul's strategy hadn't worked? 1285 01:17:09,102 --> 01:17:10,582 I can't help but think 1286 01:17:10,626 --> 01:17:13,237 this promising trial would've been cut short, 1287 01:17:13,280 --> 01:17:15,543 only to languish on a shelf 1288 01:17:15,587 --> 01:17:18,111 next to the thousands of other patents 1289 01:17:18,155 --> 01:17:19,896 collecting dust. 1290 01:17:19,939 --> 01:17:22,028 [Assistant] ViaCyte believes it has the key elements needed 1291 01:17:22,072 --> 01:17:25,858 to produce transformative therapies to treat diabetes. 1292 01:17:34,214 --> 01:17:35,955 Hello? I'm Greg. 1293 01:17:36,739 --> 01:17:38,262 Good. How are you? 1294 01:17:41,265 --> 01:17:43,571 [car engine revving] 1295 01:17:43,615 --> 01:17:45,791 We're going to talk about your results. 1296 01:17:45,835 --> 01:17:47,837 -[Greg] Yeah. -And when you had your surgery 1297 01:17:47,880 --> 01:17:50,448 to remove one of the small cell pouches. 1298 01:17:52,319 --> 01:17:53,756 So, I had a really good conversation 1299 01:17:53,799 --> 01:17:55,627 with a sponsor yesterday. 1300 01:17:56,062 --> 01:17:58,848 And so there are some donor cells there, 1301 01:17:58,891 --> 01:18:00,501 but there are not many of them 1302 01:18:00,545 --> 01:18:02,808 and they don't expect them to get any better 1303 01:18:02,852 --> 01:18:04,114 from this point on. 1304 01:18:05,419 --> 01:18:07,813 So, we look for C-peptide as a marker 1305 01:18:07,857 --> 01:18:10,033 of the cells actually making insulin in your bloodstream 1306 01:18:10,076 --> 01:18:12,296 and that's always been negative. 1307 01:18:12,992 --> 01:18:17,823 So, I don't know if we're not going to get any more benefit 1308 01:18:17,867 --> 01:18:20,696 from you, that it's worthwhile for you 1309 01:18:20,739 --> 01:18:23,263 to have to continue to take these medications 1310 01:18:23,307 --> 01:18:24,874 and have potential side effects 1311 01:18:24,917 --> 01:18:26,353 -and risk from the medications. -Yeah. 1312 01:18:26,397 --> 01:18:28,094 And I, had to... 1313 01:18:29,487 --> 01:18:32,446 -Yes, I feel the-- -You feel the same way. 1314 01:18:32,490 --> 01:18:35,798 Well, you've done a great job of taking care of yourself 1315 01:18:35,841 --> 01:18:38,583 and staying on top of things through this whole process. 1316 01:18:39,627 --> 01:18:42,587 So, well then that would lead me to this question, 1317 01:18:42,630 --> 01:18:45,677 which is, so you guys have a Eureka moment 1318 01:18:45,721 --> 01:18:47,461 and this is something that's going to work 1319 01:18:47,505 --> 01:18:49,507 for a large majority of the population. 1320 01:18:49,550 --> 01:18:52,205 How long would it take for your guys, 1321 01:18:52,510 --> 01:18:55,556 the cure, the solution that you found 1322 01:18:55,600 --> 01:18:58,429 to hit clinics where I'd be able to actually go 1323 01:18:58,472 --> 01:18:59,996 and get the dang thing? 1324 01:19:00,039 --> 01:19:02,650 Yeah, right. Good question. 1325 01:19:03,956 --> 01:19:06,306 That probably is at least, 1326 01:19:06,350 --> 01:19:08,787 from the time they're starting these phase one studies, 1327 01:19:08,831 --> 01:19:11,224 I'd say it's probably at least a five to seven year process. 1328 01:19:11,268 --> 01:19:12,748 Okay. 1329 01:19:14,401 --> 01:19:15,663 All right. 1330 01:19:19,058 --> 01:19:20,756 Other questions you have? 1331 01:19:24,237 --> 01:19:25,543 I don't know. 1332 01:19:28,067 --> 01:19:29,982 The more silent I get outside, 1333 01:19:30,026 --> 01:19:32,332 the more loud it gets inside my head. 1334 01:19:35,466 --> 01:19:37,773 [elevator dings] 1335 01:19:39,252 --> 01:19:43,126 [soft music] 1336 01:20:03,886 --> 01:20:07,541 So, even if the patients we've been following, Howard 1337 01:20:07,585 --> 01:20:10,153 don't seem to be producing C-peptides 1338 01:20:10,196 --> 01:20:12,416 or essentially their own insulin, 1339 01:20:12,459 --> 01:20:14,026 that's not a failure? 1340 01:20:14,418 --> 01:20:17,029 It depends upon how you define failure. 1341 01:20:17,073 --> 01:20:21,120 It's obviously a setback for these patients 1342 01:20:21,164 --> 01:20:24,123 who have volunteered their time and effort 1343 01:20:24,167 --> 01:20:27,126 to participate in these clinical trials. 1344 01:20:28,606 --> 01:20:30,738 But we've learned a lot from them 1345 01:20:30,782 --> 01:20:34,046 and we continue to tweak the implantation procedure, 1346 01:20:34,090 --> 01:20:37,180 trying to improve the engraftment process. 1347 01:20:37,223 --> 01:20:39,443 And we continue to make gains there. 1348 01:20:39,965 --> 01:20:43,142 What's the mood like at ViaCyte right now? 1349 01:20:43,186 --> 01:20:44,404 I think the mood is upbeat. 1350 01:20:44,448 --> 01:20:46,145 Everybody is excited. 1351 01:20:46,189 --> 01:20:48,495 I mean, everybody here at ViaCyte 1352 01:20:48,539 --> 01:20:51,759 is convinced our cells do a great job, 1353 01:20:51,803 --> 01:20:53,109 they work the way they're supposed to 1354 01:20:53,152 --> 01:20:55,502 and behave very physiologically. 1355 01:20:55,546 --> 01:20:58,810 They will cure type 1 diabetes. 1356 01:20:59,028 --> 01:21:01,769 There is one thing that you would like to know. 1357 01:21:02,205 --> 01:21:03,554 Yeah. 1358 01:21:03,597 --> 01:21:05,425 Remember the first patient from Minnesota. 1359 01:21:06,035 --> 01:21:07,340 Yeah. 1360 01:21:08,254 --> 01:21:11,040 We early terminated that patient 1361 01:21:11,083 --> 01:21:14,913 because of lack of C-peptide, 1362 01:21:14,957 --> 01:21:17,916 lack of potential efficacy and the like, 1363 01:21:17,960 --> 01:21:21,659 so we explained all of the remaining units. 1364 01:21:21,702 --> 01:21:24,357 Would you like to know what the histology showed? 1365 01:21:24,401 --> 01:21:25,663 Yes. 1366 01:21:26,098 --> 01:21:29,188 That were viable clumps of viable cells there. 1367 01:21:30,189 --> 01:21:33,105 So Howard, what does that mean? What's the takeaway? 1368 01:21:33,149 --> 01:21:35,499 What's my takeaway as a layperson. 1369 01:21:35,542 --> 01:21:39,633 The takeaway is that cells can survive 1370 01:21:39,677 --> 01:21:44,638 for long periods of time in this encapsulated environment. 1371 01:21:44,900 --> 01:21:46,727 And that's important. 1372 01:21:46,771 --> 01:21:48,033 That's really good news. 1373 01:21:48,904 --> 01:21:50,383 It's great news. 1374 01:21:50,818 --> 01:21:53,821 Would've been even better if we'd been seeing C-peptides, 1375 01:21:53,865 --> 01:21:56,824 but you know, you don't always get exactly what you want. 1376 01:21:56,868 --> 01:22:00,089 If you actually could talk to these patients, 1377 01:22:00,132 --> 01:22:02,178 the ones we've gotten to know well, 1378 01:22:02,961 --> 01:22:08,401 is there anything that you would tell them as a message? 1379 01:22:10,360 --> 01:22:13,972 We owe all of these subjects, a tremendous debt of gratitude. 1380 01:22:14,016 --> 01:22:17,149 Thus far, we have been able to give them a lot 1381 01:22:17,193 --> 01:22:20,892 in terms of effectively treating their own disease. 1382 01:22:20,936 --> 01:22:24,330 But we have gained a tremendous amount of knowledge, 1383 01:22:24,374 --> 01:22:28,552 which hopefully will help us get across the finish line 1384 01:22:28,595 --> 01:22:30,946 in terms of future iterations. 1385 01:22:34,210 --> 01:22:35,820 What are you thinking? 1386 01:22:36,125 --> 01:22:38,823 If it hadn't been for Greg and Maren, 1387 01:22:38,866 --> 01:22:41,782 for the other patients who participated in this trial 1388 01:22:41,826 --> 01:22:43,262 and they're up to patient 19, 1389 01:22:43,306 --> 01:22:45,395 they wouldn't be where they are today. 1390 01:22:45,438 --> 01:22:48,920 And it's been a huge sacrifice for these patients. 1391 01:23:00,714 --> 01:23:05,023 [soft music] 1392 01:23:12,944 --> 01:23:14,467 It's just been really hard on them. 1393 01:23:14,511 --> 01:23:15,816 And I wish it had worked for them, 1394 01:23:15,860 --> 01:23:19,603 but they're paving the way for others, so, 1395 01:23:22,258 --> 01:23:23,563 that's it. 1396 01:23:34,879 --> 01:23:36,576 [chair dragging] 1397 01:23:37,838 --> 01:23:40,450 I was trying to come to terms with the fact, 1398 01:23:40,493 --> 01:23:42,060 this may not work. 1399 01:23:44,236 --> 01:23:48,806 The trial wasn't over but it was for Greg and Maren. 1400 01:23:55,682 --> 01:23:57,206 [keyboard scrolling] 1401 01:24:07,520 --> 01:24:12,221 [soft music] 1402 01:24:25,364 --> 01:24:31,109 [soft piano music] 1403 01:24:33,590 --> 01:24:36,071 Any of the negative crap you hear coming from me, 1404 01:24:36,114 --> 01:24:38,856 that's subjective crap. That's Greg. 1405 01:24:39,857 --> 01:24:44,905 [soft music] 1406 01:24:52,565 --> 01:24:55,438 I know that I've been part of something very important 1407 01:24:55,481 --> 01:25:00,399 and very beneficial to us. All of us with diabetes. 1408 01:25:04,882 --> 01:25:11,323 [soft music] 1409 01:25:28,471 --> 01:25:31,604 [aircraft engine revving] 1410 01:25:32,605 --> 01:25:34,346 Officially, as of today, 1411 01:25:34,390 --> 01:25:36,914 I'm considered a failed transplant patient. 1412 01:25:40,700 --> 01:25:44,661 I have an appointment at my 1-year mark, late July 1413 01:25:44,704 --> 01:25:46,141 to get relisted. 1414 01:25:47,577 --> 01:25:50,536 I'm young, I'm healthy. So therefore I'm a priority. 1415 01:25:51,058 --> 01:25:54,453 I'm not ready physically or emotionally yet to do it again. 1416 01:25:54,497 --> 01:25:56,368 In time, maybe I will. 1417 01:26:01,634 --> 01:26:05,856 I have shared only this with a few people. 1418 01:26:06,291 --> 01:26:08,511 I will cross that bridge if people ask, 1419 01:26:08,946 --> 01:26:10,513 but it's a tremendous loss, 1420 01:26:11,253 --> 01:26:14,169 a loss I thought I was ready for, but I was not. 1421 01:26:15,953 --> 01:26:17,476 Thank you for listening. 1422 01:26:19,130 --> 01:26:23,090 [soft music] 1423 01:26:33,927 --> 01:26:35,146 [car door closing] 1424 01:26:40,934 --> 01:26:45,069 [soft music] 1425 01:26:54,687 --> 01:26:56,254 [knocking door] 1426 01:26:56,298 --> 01:26:59,649 -[Howard] Hey, -[Lisa] Good to see you. 1427 01:26:59,692 --> 01:27:01,216 -Good to see you. -Yeah. 1428 01:27:03,305 --> 01:27:07,439 We have the data that shows that the product 1429 01:27:07,483 --> 01:27:10,790 is producing insulin in the patients for the first time. 1430 01:27:12,662 --> 01:27:16,622 It's the first patients ever in the history of 1431 01:27:17,362 --> 01:27:19,973 diabetes cure research. 1432 01:27:20,017 --> 01:27:22,280 So, this is a big deal. 1433 01:27:25,240 --> 01:27:28,939 I mean, we know now that the cells work, 1434 01:27:29,374 --> 01:27:32,290 we didn't know that five years ago. 1435 01:27:35,467 --> 01:27:37,034 All the pieces are there. 1436 01:27:37,077 --> 01:27:40,559 It's just a matter now of completing the puzzle. 1437 01:27:49,612 --> 01:27:52,919 We all want stories with a beginning, 1438 01:27:52,963 --> 01:27:54,747 middle and end. 1439 01:27:55,835 --> 01:27:58,490 One where all the loose ends fit together. 1440 01:28:00,884 --> 01:28:04,409 But clinical research is messy and hard. 1441 01:28:06,019 --> 01:28:08,370 It doesn't fit into a tidy headline, 1442 01:28:08,979 --> 01:28:10,763 no matter how much you want it to. 1443 01:28:14,637 --> 01:28:17,988 The cells may not have worked for Greg and Maren, 1444 01:28:19,163 --> 01:28:23,036 but they're producing insulin in nine patients. 1445 01:28:23,907 --> 01:28:26,605 Nine patients. 1446 01:28:27,867 --> 01:28:29,086 Because of them, 1447 01:28:29,391 --> 01:28:32,394 we are one step closer to a cure. 1448 01:28:36,528 --> 01:28:39,357 But science alone isn't enough. 1449 01:28:40,271 --> 01:28:43,187 It needs a spotlight, a champion 1450 01:28:44,667 --> 01:28:46,016 and money. 1451 01:28:48,453 --> 01:28:51,456 If we rethink how we cure disease, 1452 01:28:51,848 --> 01:28:53,458 then the breakthroughs 1453 01:28:53,502 --> 01:28:56,069 that we so desperately need and want 1454 01:28:56,809 --> 01:28:58,202 will come. 1455 01:29:01,118 --> 01:29:03,686 Will we get there in five years? 1456 01:29:05,252 --> 01:29:06,906 I think we can. 1457 01:29:26,796 --> 01:29:32,018 [lighthearted music] 1458 01:29:34,020 --> 01:29:36,327 ♪ I met two angels 1459 01:29:36,371 --> 01:29:39,939 ♪ But they were in disguise 1460 01:29:40,200 --> 01:29:44,683 ♪ Took one look to realize 1461 01:29:45,467 --> 01:29:47,599 ♪ Tell them anything 1462 01:29:47,643 --> 01:29:50,123 ♪ And they will sympathize 1463 01:29:52,038 --> 01:29:56,391 ♪ These arms hold me tight 1464 01:29:56,913 --> 01:29:58,654 ♪ Old fears 1465 01:29:58,697 --> 01:30:01,570 ♪ Helped to ease them in my mind ♪ 1466 01:30:02,048 --> 01:30:06,618 ♪ New tears say that they will dry in time ♪ 1467 01:30:06,879 --> 01:30:08,315 ♪ Why me 1468 01:30:08,359 --> 01:30:13,146 ♪ How'd I get this hallelujah 1469 01:30:14,800 --> 01:30:19,326 ♪ Hallelujah 1470 01:30:20,676 --> 01:30:25,463 ♪ Laughing together like our thoughts are harmonized ♪ 1471 01:30:27,073 --> 01:30:31,469 ♪ Been that way since '95 1472 01:30:32,078 --> 01:30:37,823 ♪ Give me direction when it is hard to fight ♪ 1473 01:30:38,737 --> 01:30:42,828 ♪ Three roads, one light 1474 01:30:43,568 --> 01:30:48,138 ♪ Now and then I can lean my back to yours ♪ 1475 01:30:48,617 --> 01:30:53,535 ♪ Traveling like our feet don't touch the floor ♪ 1476 01:30:53,578 --> 01:30:55,101 ♪ Why me 1477 01:30:55,145 --> 01:30:59,628 ♪ How'd I get this hallelujah 1478 01:31:01,499 --> 01:31:06,591 ♪ Hallelujah 1479 01:31:06,635 --> 01:31:11,553 ♪ Hallelujah 1480 01:31:11,596 --> 01:31:13,076 ♪ Why me 1481 01:31:13,119 --> 01:31:19,735 ♪ How'd I get this hallelujah 1482 01:31:19,996 --> 01:31:25,175 ♪ I had a best friend but she has come to pass ♪ 1483 01:31:26,306 --> 01:31:31,050 ♪ One I wish I could see now 1484 01:31:31,573 --> 01:31:37,492 ♪ You always remind me that memories will last ♪ 1485 01:31:38,057 --> 01:31:42,932 ♪ These arms reach out 1486 01:31:43,193 --> 01:31:47,676 ♪ You were there to protect me like a shield ♪ 1487 01:31:48,241 --> 01:31:52,768 ♪ Long hair running with me through the field ♪ 1488 01:31:53,420 --> 01:32:00,123 ♪ Everywhere you've been with me all along ♪ 1489 01:32:02,255 --> 01:32:03,561 ♪ Why me 1490 01:32:03,605 --> 01:32:06,912 ♪ How'd I get this hallelujah 1491 01:32:07,434 --> 01:32:09,088 ♪ Why me 1492 01:32:09,132 --> 01:32:12,352 ♪ How'd I get this hallelujah 1493 01:32:12,396 --> 01:32:14,180 ♪ Why me 1494 01:32:14,224 --> 01:32:19,316 ♪ How'd I get this hallelujah 1495 01:32:20,360 --> 01:32:24,234 ♪ Hallelujah 1496 01:32:57,354 --> 01:32:59,399 [dog barking] 1497 01:33:00,270 --> 01:33:03,099 [keyboard clattering] 1498 01:33:05,971 --> 01:33:09,971 [lighthearted guitar music]